Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study

被引：6

作者：

Folsom, Aaron R. ^{[1
]}

Nambi, Vijay ^{[2
,3
]}

Pankow, James S. ^{[1
]}

Tang, Weihong ^{[1
]}

Farbakhsh, Kian ^{[1
]}

Yamagishi, Kazumasa ^{[4
]}

Boerwinkle, Eric ^{[5
]}

机构：

[1] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA

[2] Baylor Coll Med, Dept Med, Div Atherosclerosis & Vasc Med, Houston, TX 77030 USA

[3] Methodist DeBakey Heart & Vasc Ctr, Ctr Cardiovasc Prevent, Houston, TX 77030 USA

[4] Univ Tsukuba, Fac Med, Dept Publ Hlth Med, Tsukuba, Ibaraki 3058575, Japan

[5] Univ Texas Hlth Sci Ctr, Ctr Human Genet, Sch Publ Hlth, Houston, TX 77030 USA

来源：

ATHEROSCLEROSIS | 2012年 / 224卷 / 02期

关键词：

Coronary disease; Prospective study; 9p21; SNP; CHROMOSOME; 9P21; MYOCARDIAL-INFARCTION; ASSOCIATION ANALYSIS; ARTERY-DISEASE; LOCUS; SUSCEPTIBILITY; VARIANT; METAANALYSIS;

D O I：

10.1016/j.atherosclerosis.2012.08.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To determine whether the 9p21 SNP association with coronary heart disease is modified by other classical or novel risk markers. Methods: The 9p21 SNP (rs10757274) and multiple risk markers were measured in the Atherosclerosis Risk in Communities Study, and incident coronary disease events were ascertained. Effect modification (interaction) of the 9p21 SNP with risk markers was tested in Cox proportional hazard regression models. Results: The incidence rates of coronary heart disease per 1000 person-years were 14.4, 17.0, and 18.7 for AA, AG, and GG genotypes, yielding hazard ratios of 1.0, 1.20 (95% CI - 1.07-1.36), and 1.34 (95% CI - 1.16-1.53). There was no meaningful evidence of an interaction(all p-interaction > 0.04) between 9p21 SNP and any of 14 other risk markers for coronary heart disease. These included novel markers not previously explored for 9p21 interaction (e. g., cardiac troponin T and N-terminal pro-brain natriuretic peptide). Conclusion: Our study extends evidence that the 9p21 SNP association with coronary heart disease is not modified by classical or novel risk markers. Our findings therefore rule out additional plausible pathways by which 9p21 might have increased coronary heart disease risk. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：435 / 439

页数：5

共 25 条

[1] Large Scale Association Analysis of Novel Genetic Loci for Coronary Artery Disease [J].

Amouyel, Philippe ;

Arveiler, Dominique ;

Boekholdt, S. Matthijs ;

Braund, Peter ;

Bruse, Petra ;

Bumpstead, Suzannah J. ;

Bugert, Peter ;

Cambien, Francois ;

Danesh, John ;

Deloukas, Panos ;

Doering, Angela ;

Ducimetiere, Pierre ;

Dunn, Ruth M. ;

El Mokhtari, Nour-Eddine ;

Erdmann, Jeanette ;

Evans, Alun ;

Ewels, Phil ;

Ferrieres, Jean ;

Fischer, Marcus ;

Frossard, Philippe ;

Garner, Stephen ;

Gieger, Christian ;

Gohri, Mohammed J. R. ;

Goodall, Alison H. ;

Grosshennig, Anika ;

Hall, Alistair ;

Hardwick, Rob ;

Haukijarvi, Ari ;

Hengstenberg, Christian ;

Illig, Thomas ;

Karvanen, Juha ;

Kastelein, John ;

Kee, Frank ;

Khaw, Kay-Tee ;

Klueter, Harald ;

Koenig, Inke R. ;

Kuulasmaa, Kari ;

Laiho, Paivi ;

Luc, Gerald ;

Maerz, Winfried ;

McGinnis, Ralph ;

McLaren, William ;

Meisinger, Christa ;

Morrison, Caroline ;

Ou, Xiodan ;

Ouwehand, Willem H. ;

Preuss, Michael ;

Proust, Carole ;

Ravindrarajah, Radhi ;

Renner, Wilfried .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (05) :774-U356

[2] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[3] Genetic Mechanisms Mediating Atherosclerosis Susceptibility at the Chromosome 9p21 Locus [J].

Cunnington, Michael S. ;

Keavney, Bernard .

CURRENT ATHEROSCLEROSIS REPORTS, 2011, 13 (03) :193-201

[4] Gene Dosage of the Common Variant 9p21 Predicts Severity of Coronary Artery Disease [J].

Dandona, Sonny ;

Stewart, Alexandre F. R. ;

Chen, Li ;

Williams, Kathryn ;

So, Derek ;

O'Brien, Ed ;

Glover, Christopher ;

LeMay, Michel ;

Assogba, Olivia ;

Vo, Lan ;

Wang, Yan Qing ;

Labinaz, Marino ;

Wells, George A. ;

McPherson, Ruth ;

Roberts, Robert .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (06) :479-486

[5] The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study [J].

Do, Ron ;

Xie, Changchun ;

Zhang, Xiaohe ;

Mannisto, Satu ;

Harald, Kennet ;

Islam, Shofiqul ;

Bailey, Swneke D. ;

Rangarajan, Sumathy ;

McQueen, Matthew J. ;

Diaz, Rafael ;

Liu Lisheng ;

Wang, Xingyu ;

Silander, Kaisa ;

Peltonen, Leena ;

Yusuf, Salim ;

Salomaa, Veikko ;

Engert, James C. ;

Anand, Sonia S. .

PLOS MEDICINE, 2011, 8 (10)

[6] Interaction Between Poor Glycemic Control and 9p21 Locus on Risk of Coronary Artery Disease in Type 2 Diabetes [J].

Doria, Alessandro ;

Wojcik, Joanna ;

Xu, Rui ;

Gervino, Ernest V. ;

Hauser, Thomas H. ;

Johnstone, Michael T. ;

Nolan, David ;

Hu, Frank B. ;

Warram, James H. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (20) :2389-2397

[7] The Coronary Artery Disease-Associated 9p21 Variant and Later Life 20-Year Survival to Cohort Extinction [J].

Dutta, Ambarish ;

Henley, William ;

Lang, Iain A. ;

Murray, Anna ;

Guralnik, Jack ;

Wallace, Robert B. ;

Melzer, David .

CIRCULATION-CARDIOVASCULAR GENETICS, 2011, 4 (05) :542-548

[8] Sample size requirements for association studies of gene-gene interaction [J].

Gauderman, WJ .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 155 (05) :478-484

[9] The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm [J].

Helgadottir, Anna ;

Thorleifsson, Gudmar ;

Magnusson, Kristinn P. ;

Gretarsdottir, Solveig ;

Steinthorsdottir, Valgerdur ;

Manolescu, Andrei ;

Jones, Gregory T. ;

Rinkel, Gabriel J. E. ;

Blankensteijn, Jan D. ;

Ronkainen, Antti ;

Jaaskelainen, Juha E. ;

Kyo, Yoshiki ;

Lenk, Guy M. ;

Sakalihasan, Natzi ;

Kostulas, Konstantinos ;

Gottsater, Anders ;

Flex, Andrea ;

Stefansson, Hreinn ;

Hansen, Torben ;

Andersen, Gitte ;

Weinsheimer, Shantel ;

Borch-Johnsen, Knut ;

Jorgensen, Torben ;

Shah, Svati H. ;

Quyyumi, Arshed A. ;

Granger, Christopher B. ;

Reilly, Muredach P. ;

Austin, Harland ;

Levey, Allan I. ;

Vaccarino, Viola ;

Palsdottir, Ebba ;

Walters, G. Bragi ;

Jonsdottir, Thorbjorg ;

Snorradottir, Steinunn ;

Magnusdottir, Dana ;

Gudmundsson, Gudmundur ;

Ferrell, Robert E. ;

Sveinbjornsdottir, Sigurlaug ;

Hernesniemi, Juha ;

Niemela, Mika ;

Limet, Raymond ;

Andersen, Karl ;

Sigurdsson, Gunnar ;

Benediktsson, Rafn ;

Verhoeven, Eric L. G. ;

Teijink, Joep A. W. ;

Grobbee, Diederick E. ;

Rader, Daniel J. ;

Collier, David A. ;

Pedersen, Oluf .

NATURE GENETICS, 2008, 40 (02) :217-224

[10] A common variant on chromosome 9p21 affects the risk of myocardial infarction [J].

Helgadottir, Anna ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Gretarsdottir, Solveig ;

Blondal, Thorarinn ;

Jonasdottir, Aslaug ;

Jonasdottir, Adalbjorg ;

Sigurdsson, Asgeir ;

Baker, Adam ;

Palsson, Arnar ;

Masson, Gisli ;

Gudbjartsson, Daniel F. ;

Magnusson, Kristinn P. ;

Andersen, Karl ;

Levey, Allan I. ;

Backman, Valgerdur M. ;

Matthiasdottir, Sigurborg ;

Jonsdottir, Thorbjorg ;

Palsson, Stefan ;

Einarsdottir, Helga ;

Gunnarsdottir, Steinunn ;

Gylfason, Arnaldur ;

Vaccarino, Viola ;

Hooper, W. Craig ;

Reilly, Muredach P. ;

Granger, Christopher B. ;

Austin, Harland ;

Rader, Daniel J. ;

Shah, Svati H. ;

Quyyumi, Arshed A. ;

Gulcher, Jeffrey R. ;

Thorgeirsson, Gudmundur ;

Thorsteinsdottir, Unnur ;

Kong, Augustine ;

Stefansson, Kari .

SCIENCE, 2007, 316 (5830) :1491-1493

← 1 2 3 →