Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus

被引:22
作者
Mobbs, Charles V. [1 ]
Moreno, Cesar L.
Poplawski, Michael
机构
[1] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA
关键词
lifespan; glucose metabolism; dietary restriction; CREB-BINDING PROTEIN; LIFE-SPAN; CALORIE RESTRICTION; CAENORHABDITIS-ELEGANS; DIETARY RESTRICTION; SACCHAROMYCES-CEREVISIAE; BETA-HYDROXYBUTYRATE; PERIPHERAL-TISSUES; OXIDATIVE STRESS; ARCUATE NUCLEUS;
D O I
10.1016/j.tem.2013.05.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We propose that energy balance, glucose homeostasis, and aging are all regulated largely by the same nutrient-sensing neurons in the ventromedial hypothalamus (VMH). Although the central role of these neurons in regulating energy balance is clear, their role in regulating glucose homeostasis has only recently become more clear. This latter function may be most relevant to aging and lifespan by controlling the rate of glucose metabolism. Specifically, glucose-sensing neurons in VMH promote peripheral glucose metabolism, and dietary restriction, by reducing glucose metabolism in these neurons, reduces glucose metabolism of the rest of the body, thereby increasing lifespan. Here we discuss recent studies demonstrating the key role of hypothalamic neurons in driving aging and age-related diseases.
引用
收藏
页码:488 / 494
页数:7
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