Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: Current state and perspectives

被引：571
作者：
Li, Jianhui [1 ,2 ]
Zhuang, Shaoling [3 ]
机构：
[1] Hong Kong Polytech Univ, Nanotechnol Ctr, Inst Text & Clothing, Hung Hom,Kowloon, Hong Kong 999077, Peoples R China
[2] Univ Chinese Acad Sci, Shenzhen Hosp, Minist Sci & Educ, Shenzhen 518000, Peoples R China
[3] Shenzhen Peoples Hosp, Div Neonatol, Shenzhen 518000, Peoples R China
来源：
EUROPEAN POLYMER JOURNAL | 2020年 / 138卷
基金：
中国国家自然科学基金;
关键词：
Chitosan; Antibacterial activity; Antibacterial mechanism; Influencing factor; Perspective; WATER-SOLUBLE CHITOSAN; ANTIMICROBIAL ACTIVITY; MOLECULAR-WEIGHT; ANTIFUNGAL ACTIVITY; COMMERCIAL CHITOSAN; ESCHERICHIA-COLI; CELL-MEMBRANE; CHITIN; MODE; NANOCOMPOSITE;
D O I：
10.1016/j.eurpolymj.2020.109984
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Chitosan has fascinating antibacterial activity, good biodegradation, outstanding biocompatibility, non-toxicity and excellent physical and chemical properties. As a result, chitosan has been widely used in the field of anti-bacterial. Chitosan and its derivatives show antibacterial activity against fungi, gram-positive bacteria and gramnegative bacteria. In recent years, there have been some reviews about the antibacterial activity of chitosan and its derivatives. This review adds many valuable concerns on the basis of those previous reviews. For example, composite of chitosan and metal, composite of chitosan and metal oxide, etc. This review will systematically analyze various influencing factors of chitosan, so as to clearly summarize the antibacterial mechanism of chitosan. Finally, the challenges and prospects of chitosan-based materials as antimicrobial agents are assessed and commented.
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页数：12
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