Systemic Problems: A perspective on stem cell aging and rejuvenation

被引：53

作者：

Conboy, Irina M. ^{[1
]}

Conboy, Michael J. ^{[1
]}

Rebo, Justin ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94709 USA

来源：

AGING-US | 2015年 / 7卷 / 10期

关键词：

parabiosis; aging; rejuvenation; stem cells; neurogenesis; SKELETAL-MUSCLE REGENERATION; HESC-SECRETED PROTEINS; SATELLITE CELLS; DNA-DAMAGE; HIPPOCAMPAL NEUROGENESIS; EPIGENETIC CHANGES; COGNITIVE FUNCTION; PROGENITOR CELLS; SENESCENT CELLS; AGED MUSCLE;

D O I：

10.18632/aging.100819

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are "beyond parabiosis" for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.

引用

页码：754 / 765

页数：12

共 106 条

[1] Oxytocin reverses osteoporosis in a sex-dependent manner [J].

Beranger, Guillaume E. ;

Djedaini, Mansour ;

Battaglia, Severine ;

Roux, Christian H. ;

Scheideler, Marcel ;

Heymann, Dominique ;

Amri, Ez-Zoubir ;

Pisani, Didier F. .

FRONTIERS IN ENDOCRINOLOGY, 2015, 6

[2] p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice [J].

Bernet, Jennifer D. ;

Doles, Jason D. ;

Hall, John K. ;

Tanaka, Kathleen Kelly ;

Carter, Thomas A. ;

Olwin, Bradley B. .

NATURE MEDICINE, 2014, 20 (03) :265-271

[3] A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice [J].

Biressi, Stefano ;

Miyabara, Elen H. ;

Gopinath, Suchitra D. ;

Carlig, Poppy M. M. ;

Rando, Thomas A. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (267)

[4] Aging, stem cells, and mammalian target of rapamycin: A prospect of pharmacologic rejuvenation of aging stem cells [J].

Blagosklonny, Mikhail V. .

REJUVENATION RESEARCH, 2008, 11 (04) :801-808

[5] Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging [J].

Blagosklonny, Mikhail V. .

AGING-US, 2012, 4 (03) :159-165

[6] Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells [J].

Borodkina, Aleksandra ;

Shatrova, Alla ;

Abushik, Polina ;

Nikolsky, Nikolay ;

Burova, Elena .

AGING-US, 2014, 6 (06) :481-495

[7] A temporal switch from Notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis [J].

Brack, Andrew S. ;

Conboy, Irina M. ;

Conboy, Michael J. ;

Shen, Jeanne ;

Rando, Thomas A. .

CELL STEM CELL, 2008, 2 (01) :50-59

[8] Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis [J].

Brack, Andrew S. ;

Conboy, Michael J. ;

Roy, Sudeep ;

Lee, Mark ;

Kuo, Calvin J. ;

Keller, Charles ;

Rando, Thomas A. .

SCIENCE, 2007, 317 (5839) :807-810

[9] TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [J].

Bragado, Paloma ;

Estrada, Yeriel ;

Parikh, Falguni ;

Krause, Sarah ;

Capobianco, Carla ;

Farina, Hernan G. ;

Schewe, Denis M. ;

Aguirre-Ghiso, Julio A. .

NATURE CELL BIOLOGY, 2013, 15 (11) :1351-U210

[10] Loss of TGF-β1 leads to increased neuronal cell death and microgliosis in mouse brain [J].

Brionne, TC ;

Tesseur, I ;

Masliah, E ;

Wyss-Coray, T .

NEURON, 2003, 40 (06) :1133-1145

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