Animal models of nephrotic syndrome

被引：23
作者：
Simic, Ivana [1 ]
Tabatabaeifar, Mansoureh [1 ]
Schaefer, Franz [1 ]
机构：
[1] Heidelberg Univ, Ctr Pediat & Adolescent Med, Div Pediat Nephrol, D-69120 Heidelberg, Germany
来源：
PEDIATRIC NEPHROLOGY | 2013年 / 28卷 / 11期
关键词：
Steroid-resistant nephrotic syndrome; Mouse; Zebrafish; Knock-out; Knock-in; IMMUNE-COMPLEX GLOMERULONEPHRITIS; BOVINE SERUM-ALBUMIN; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; SEVERE RENAL-DISEASE; MEMBRANOUS NEPHROPATHY; MICE LACKING; MOUSE MODEL; HEYMANN NEPHRITIS; MONOCLONAL-ANTIBODY; EPITHELIAL-CELLS;
D O I：
10.1007/s00467-012-2376-5
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Animal models of proteinuria and nephrotic syndrome are essential tools for studying the mechanisms of action of abnormalities in individual components of the podocyte and glomerular basement membrane. In recent years a variety of in vivo models have been developed to elucidate the function of specific podocyte proteins and their role in the pathogenesis of proteinuria and glomerulosclerosis. In this overview of the animal models currently available we discuss their contribution to our mechanistic understanding and their potential use in screening for novel targeted therapies of steroid-resistant nephrotic syndrome.
引用
收藏
页码：2079 / 2088
页数：10
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