A convenient synthesis of azido peptides by post-assembly diazo transfer on the solid phase applicable to large peptides

被引：33

作者：

Rijkers, DTS ^{[1
]}

van Vugt, HHR ^{[1
]}

Jacobs, HJF ^{[1
]}

Liskamp, RMJ ^{[1
]}

机构：

[1] Univ Utrecht, Fac Pharmaceut Sci, Utrecht Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 20期

关键词：

azides; azido peptides; diazo transfers; solid phase synthesis;

D O I：

10.1016/S0040-4039(02)00629-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the conversion of solid phase bound peptide amines into azides by a diazo transfer using triflyl azide in the presence of divalent copper ions is described. alpha-Azido acids and azido peptides-up to 30 amino acids in length-are obtained in good yields and high purities after cleavage from the solid support. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：3657 / 3660

页数：4

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