Selective Reduction of Amides to Amines by Boronic Acid Catalyzed Hydrosilylation

被引：100

作者：

Li, Yuehui ^{[1
]}

Molina de la Torre, Jesus A. ^{[2
]}

Grabow, Kathleen ^{[1
]}

Bentrup, Ursula ^{[1
]}

Junge, Kathrin ^{[1
]}

Zhou, Shaolin ^{[3
]}

Brueckner, Angelika ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

[2] Univ Valladolid, Fac Ciencias, IU CINQUIMA Quim Inorgan, Valladolid 47071, Spain

[3] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 44期

关键词：

amides; boron; homogeneous catalysis; organocatalysis; reduction; METAL-FREE REDUCTION; TERTIARY AMIDES; SECONDARY AMIDES; CARBOXYLIC-ACIDS; COMPLEX; ACTIVATION; KETONES; FACILE; ESTERS; MILD;

D O I：

10.1002/anie.201304495

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Not a 'B'ore! Benzothiophene-based boronic acids catalyze the reduction of tertiary, secondary, and primary amides in the presence of a hydrosilane. The reaction demonstrates good functional-group tolerance. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11577 / 11580

页数：4

共 55 条

[1]

Addis, 2011, ANGEW CHEM, V123, P6128

[2] Selective Reduction of Carboxylic Acid Derivatives by Catalytic Hydrosilylation [J].