Investigation of protective effects of Erythrina velutina extract against MMS induced damages in the root meristem cells of Allium cepa

被引:7
作者
Silva, Deborah S. B. S.
Barboza, Benhur [1 ]
Garcia, Anuska C. F. S.
de Oliveira, Betejane
Estevam, Charles S. [2 ]
Neto, Vitor A. [2 ]
Santos, Andre L. L. M. [2 ]
Dias, Antonio S. [2 ]
Scher, Ricardo [3 ]
Pantaleao, Silmara M. [1 ]
机构
[1] Univ Fed Sergipe, Dept Biol, BR-49100000 Sao Cristovao, SE, Brazil
[2] Univ Fed Sergipe, Dept Fisiol, BR-49100000 Sao Cristovao, SE, Brazil
[3] Univ Fed Sergipe, Dept Morfol, BR-49100000 Sao Cristovao, SE, Brazil
来源
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2013年 / 23卷 / 02期
关键词
Allium cepa; antigenotoxicity; chromosomal aberration; Erythrina velutina; Fabaceae; root growth; ANTI-GENOTOXICITY; FLAVONOIDS; PLANTS; ASSAYS;
D O I
10.1590/S0102-695X2013005000006
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Erythrina velutina Willd., Fabaceae, is a medicinal plant that can be found in the tropics and subtropics, including in the semi-arid northeastern Brazil. It is commonly used in folk medicine to treat anxiety, agitation and insomnia. E. velutina has been known to present analgesic, anti-inflammatory and antibacterial activities, however, it is unknown if this plant present a protective effect on DNA. We assessed the antigenotoxic effect of E. velutina against the genotoxic effects induced by MMS in the root meristem cells of Allium cepa. Three concentrations of the aqueous extract (100, 200 and 400 mg/L) of this medicinal plant were used in three different types of treatment (pre-, post- and simultaneous). The effects of the extracts on the root meristem cells of A. cepa were analyzed at both macroscopic and microscopic levels. Protective effects were observed at higher concentrations in pre-treatment and in simultaneous treatment. The results suggest that E. velutina may present antigenotoxic properties and demonstrate its chemopreventive potential.
引用
收藏
页码:273 / 278
页数:6
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