Zebrafish sirt5 Negatively Regulates Antiviral Innate Immunity by Attenuating Phosphorylation and Ubiquitination of mavs

被引：9

作者：

Chen, Xiaoyun ^{[1
,2
]}

Fan, Sijia ^{[1
,2
]}

Zhu, Chunchun ^{[1
,2
]}

Liao, Qian ^{[1
,2
]}

Tang, Jinhua ^{[1
,2
]}

Yu, Guangqing ^{[1
,2
]}

Cai, Xiaolian ^{[1
,3
,4
]}

Ouyang, Gang ^{[1
,3
,4
]}

Xiao, Wuhan ^{[1
,2
,3
,4
,5
]}

Liu, Xing ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Peoples R China

[4] Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China

[5] Hubei Hongshan Lab, Wuhan, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY | 2022年 / 209卷 / 06期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

PATTERN-RECOGNITION RECEPTORS; INDUCIBLE GENE-I; NF-KAPPA-B; PROTEIN; ACETYLATION; ACTIVATION; IL-1-BETA; SIRTUINS; ADAPTER; ACIDS;

D O I：

10.4049/jimmunol.2100983

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The signaling adaptor MAVS is a critical determinant in retinoic acid-inducible gene 1-like receptor signaling, and its activation is tightly controlled by multiple mechanisms in response to viral infection, including phosphorylation and ubiquitination. In this article, we demonstrate that zebrafish sirt5, one of the sirtuin family proteins, negatively regulates mavs-mediated antiviral innate immunity. Sirt5 is induced by spring viremia of carp virus (SVCV) infection and binds to mavs, resulting in attenuating phosphorylation and ubiquitination of mavs. Disruption of sirt5 in zebrafish promotes survival ratio after challenge with SVCV. Consistently, the antiviral responsive genes are enhanced, and the replication of SVCV is diminished in sirt5-dificient zebrafish. Therefore, we reveal a function of zebrafish sirt5 in the negative regulation of antiviral innate immunity by targeting mavs.

引用

页码：1165 / 1172

页数：8

共 45 条

[1] Regulation of cGAS- and RLR-mediated immunity to nucleic acids [J].

Ablasser, Andrea ;

Hur, Sun .

NATURE IMMUNOLOGY, 2020, 21 (01) :17-29

[2] RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate [J].

Ablasser, Andrea ;

Bauernfeind, Franz ;

Hartmann, Gunther ;

Latz, Eicke ;

Fitzgerald, Katherine A. ;

Hornung, Veit .

NATURE IMMUNOLOGY, 2009, 10 (10) :1065-U40

[3] Spring viremia of carp (SVC) [J].

Ahne, W ;

Bjorklund, HV ;

Essbauer, S ;

Fijan, N ;

Kurath, G ;

Winton, JR .

DISEASES OF AQUATIC ORGANISMS, 2002, 52 (03) :261-272

[4] SnapShot: Mammalian Sirtuins [J].

Anderson, Kristin A. ;

Green, Michelle F. ;

Huynh, Frank K. ;

Wagner, Gregory R. ;

Hirschey, Matthew D. .

CELL, 2014, 159 (04)

[5] EMBRYONIC LETHALITY AND LIVER DEGENERATION IN MICE LACKING THE RELA COMPONENT OF NF-KAPPA-B [J].

BEG, AA ;

SHA, WC ;

BRONSON, RT ;

GHOSH, S ;

BALTIMORE, D .

NATURE, 1995, 376 (6536) :167-170

[6] Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease [J].

Cao, Xuetao .

NATURE REVIEWS IMMUNOLOGY, 2016, 16 (01) :35-50

[7] Zebrafish IκB kinase 1 negatively regulates NF-κB activity [J].

Correa, RG ;

Matsui, T ;

Tergaonkar, V ;

Rodriguez-Esteban, C ;

Izpisua-Belmonte, JC ;

Verma, IM .

CURRENT BIOLOGY, 2005, 15 (14) :1291-1295

[8] FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection [J].

Dai, Tong ;

Wu, Liming ;

Wang, Shuai ;

Wang, Jing ;

Xie, Feng ;

Zhang, Zhengkui ;

Fang, Xiuwu ;

Li, Jingxian ;

Fang, Pengfei ;

Li, Fang ;

Jin, Ke ;

Dai, Jianfeng ;

Yang, Bing ;

Zhou, Fangfang ;

van Dam, Hans ;

Cai, Dachuan ;

Huang, Huizhe ;

Zhang, Long .

CELL HOST & MICROBE, 2018, 24 (06) :776-+

[9] Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase [J].

Du, Jintang ;

Zhou, Yeyun ;

Su, Xiaoyang ;

Yu, Jiu Jiu ;

Khan, Saba ;

Jiang, Hong ;

Kim, Jungwoo ;

Woo, Jimin ;

Kim, Jun Huyn ;

Choi, Brian Hyun ;

He, Bin ;

Chen, Wei ;

Zhang, Sheng ;

Cerione, Richard A. ;

Auwerx, Johan ;

Hao, Quan ;

Lin, Hening .

SCIENCE, 2011, 334 (6057) :806-809

[10] Recent progress in the biology and physiology of sirtuins [J].

Finkel, Toren ;

Deng, Chu-Xia ;

Mostoslavsky, Raul .

NATURE, 2009, 460 (7255) :587-591

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