Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression

被引：228

作者：

Lam, SH

Wu, YL

Vega, VB

Miller, LD

Spitsbergen, J

Tong, Y

Zhan, HQ

Govindarajan, KR

Lee, S

Mathavan, S

Murthy, KRK

Buhler, DR

Liu, ET

Gong, ZY

机构：

[1] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore

[2] Agcy Sci Technol & Res, Genome Inst Singapore, Singapore 138672, Singapore

[3] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA

[4] Oregon State Univ, Marine Freshwater Biomed Sci Ctr, Corvallis, OR 97331 USA

来源：

NATURE BIOTECHNOLOGY | 2006年 / 24卷 / 01期

关键词：

D O I：

10.1038/nbt1169

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.

引用

页码：73 / 75

页数：3

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