New strategies for neuroprotection in glaucoma, a disease that affects the central nervous system

被引:40
作者
Nucci, Carlo [1 ]
Russo, Rossella [2 ,3 ]
Martucci, Alessio [1 ]
Giannini, Clarissa [1 ]
Garaci, Francesco [4 ,5 ]
Floris, Roberto [4 ]
Bagetta, Giacinto [2 ,3 ]
Morrone, Luigi Antonio [2 ,3 ]
机构
[1] Univ Roma Tor Vergata, Dept Expt Med & Surg, Ophthalmol Unit, Rome, Italy
[2] Univ Calabria, Dept Pharm Nutr & Hlth Sci, Arcavacata Di Rende, Italy
[3] Univ Calabria, Univ Ctr Adapt Disorders & Head Pain, Sect Neuropharmacol Normal & Pathol Neuronal Plas, Arcavacata Di Rende, Italy
[4] Univ Roma Tor Vergata, Dept Biomed & Prevent, UOC Neuroradiol, Rome, Italy
[5] San Raffaele Cassino FR, Cassino, FR, Italy
关键词
Glaucoma; Neuroprotection; Retinal ganglion cell; Optic nerve; Intraocular pressure; RETINAL GANGLION-CELLS; LATERAL GENICULATE-NUCLEUS; HEREDITARY OPTIC NEUROPATHY; OPEN-ANGLE GLAUCOMA; INTRAOCULAR-PRESSURE; NEUROTROPHIC FACTOR; GLUTAMATE CONCENTRATION; ALZHEIMERS-DISEASE; AQUEOUS-HUMOR; RAT MODEL;
D O I
10.1016/j.ejphar.2016.04.030
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Glaucoma is a disease where retinal ganglion cells (RGC) are specifically affected though a number of evidences endorse the hypothesis that glaucoma is a neuro-degenerative disorder of the central nervous system and suggest a possible connection between glaucomatous damage and cerebrovascular alterations. The mechanisms underlying RGC loss are not yet fully known but alterations of the autophagy machinery have been recently proposed as a potential contributing factor as for Alzheimer's disease. Here we review the current literature on new strategies for neuroprotection in glaucoma, focusing on pharmacologic strategies to minimize RGC damage. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:119 / 126
页数:8
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