The complex, effective and innovative cleaning technology for lipid-rich wastewater and pipelines contaminated by lipids, was developed. For this purpose, laboratory experiments were performed to verify the efficiency of bacterial preparation (Enterobacter aerogenes E13, Arthrobacter sp. N3 and Bacillus coagulans S1) to degrade the grease in water and in drainpipes. The results showed that selected microorganisms intensively degrade grease to light odourless precipitate, water and CO2, thus could be applied in industry. For optimization of technological cleaning processes, the response surface methodology was used. The optimal parameters for biological model wastewater treatment were determined: concentration of grease -4.5-6.0 g/l, amount of bacterial preparation -5.5-6.0%, pH -8-9. Due to optimization, the grease degradation rate increased by 20-30%. The optimization of drainpipe cleaning technology was achieved in two stages. During the first stage, the experiments were performed in laboratory flasks; during the second stage, optimized cleaning process was tested in a pilot plant. The following optimal parameters were set: pH 8, amount of bacterial preparation 1.25 l/m(2) and harness of water -0.0 mmol/l. In water of medium hardness, the rate of biodegradation process is 15-20% less. A satisfactory efficiency of grease biodegradation was achieved in the pilot plant: the 86.7% of grease were digested in 21 days. Besides, living microorganisms were detected inside the clean drainpipe.