FACILE ONE-POT PROCEDURE FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE DERIVATIVES

被引：6

作者：

Yin, Guodong ^{[1
]}

Ma, Junrui ^{[1
]}

Shi, Houqiang ^{[1
]}

Tao, Qing ^{[1
]}

机构：

[1] Hubei Normal Univ, Coll Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China

来源：

HETEROCYCLES | 2012年 / 85卷 / 08期

基金：

中国国家自然科学基金;

关键词：

2-Aminothiazole; One-Pot Reaction; Hantzsch Synthesis; BETA-KETO-ESTERS; ALPHA-BROMINATION; EFFICIENT SYNTHESIS; N-BROMOSUCCINIMIDE; CARBONYL-COMPOUNDS; DISCOVERY; MILD; HALOGENATION; CONVERSION; THIAZOLE;

D O I：

10.3987/COM-12-12510

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile, efficient synthesis of 2-aminothiazole derivatives by the reaction of easily available aromatic methyl ketones with thiourea/N-substituted thioureas in the presence of copper(II) bromide was developed. The reaction underwent a one-pot alpha-bromination/cyclization process.

引用

页码：1941 / 1948

页数：8

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