The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis

被引：60
作者：
Coll, Anthony P. [1 ]
Yeo, Giles S. H.
机构：
[1] Univ Cambridge, Wellcome Trust MRC Inst Metab Sci, MRC Metab Dis Unit, Metab Res Labs, Cambridge CB2 0QQ, England
来源：
CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 06期
基金：
英国医学研究理事会;
关键词：
REDUCES FOOD-INTAKE; PROOPIOMELANOCORTIN NEURONS; BODY-WEIGHT; INSULIN SENSITIVITY; MELANOCORTIN-4; RECEPTOR; ARCUATE NUCLEUS; LEPTIN ACTION; TANYCYTES; GROWTH; HYPERPHAGIA;
D O I：
10.1016/j.coph.2013.09.010
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Molecules acting in the central nervous system play a critical role in the control of both energy and glucose homeostasis. The hypothalamus consists of a highly diverse collection of interconnected neurons and supporting glial cells that allow this region of the brain to sense and respond to a diverse range of hormonal and metabolic signals. We review recent advances in our understanding of the anatomical architecture and molecular mechanisms within the hypothalamus and how these facilitate the orchestration of systemic metabolic processes.
引用
收藏
页码：970 / 976
页数：7
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