Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti-Aspergillus and antigenotoxic activities

被引:19
|
作者
Aprotosoaie, Ana Clara [1 ]
Miron, Anca [1 ]
Ciocarlan, Nina [2 ]
Brebu, Mihai [3 ]
Rosu, Craita Maria [4 ]
Trifan, Adriana [1 ]
Vochita, Gabriela [4 ]
Gherghel, Daniela [4 ]
Luca, Simon Vlad [1 ]
Nita, Alexandru [5 ]
Costache, Irina-Iuliana [6 ]
Mihai, Cosmin Teodor [4 ,7 ]
机构
[1] Grigore T Popa Univ Med & Pharm Iasi, Fac Pharm, Univ Str 16, Iasi 700115, Romania
[2] Moldavian Acad Sci, Bot Garden, Padurii Str 18, Kishinev 2002, Moldova
[3] Petru Poni Inst Macromol Chem, Phys Chem Polymers Lab, Grigore Ghica Voda Alley 41A, Iasi 70048, Romania
[4] Natl Inst Res & Dev Biol Sci, Biol Res Inst, Lascar Catargi Str 47, Iasi 700107, Romania
[5] Alexandru Ioan Cuza Univ, Fac Biol, Carol I Ave 22, Iasi 700505, Romania
[6] Grigore T Popa Univ Med & Pharm, Fac Med, Univ Str 16, Iasi 700115, Romania
[7] Grigore T Popa Univ Med & Pharm, CEMEX, Univ Str 16, Iasi 700115, Romania
关键词
antigenotoxicity; bioactivity; chemical composition; essential oils; Thymus species; L. ESSENTIAL OIL; DNA-DAMAGE; VULGARIS L; ANTIFUNGAL ACTIVITY; ANTIBACTERIAL; ASSAY; WILD; PROLIFERATION; OFFICINALIS; MODULATION;
D O I
10.1002/ffj.3490
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Thymus species are important aromatic, medicinal and culinary plants with a significant economic value. This study evaluated for the first time the chemical composition and in vitro bioactivities of the essential oils (EOs) from five Moldavian Thymus species (T. vulgaris, T. x citriodorus, T. calcareus) and cultivars (T. vulgaris 'Faustini', T. citriodorus 'Aureus'). The main compounds in Thymus EOs were: thymol in T. vulgaris and T. calcareus EOs (55.44% and 55.45%, respectively), lavandulol in T. x citriodorus EO (54.27%), and geraniol in T. citriodorus 'Aureus' and T. vulgaris 'Faustini' EOs (60.31% and 31.45%, respectively). T. vulgaris and T. calcareus EOs showed the most potent antioxidant activities (EC50=0.003 mg/mL in ABTS radical cation scavenging assay) and exhibited significant inhibitory effects against aflatoxin-producing Aspergillus flavus fungus (MIC=0.25 mu L/mL). At doses that provided micromolar concentrations of thymol, T. vulgaris and T. calcareus EOs acted genoprotective at preventive and interventional levels against H2O2-induced genomic damage in V79 cells, the former being more active (6.21% and 5.52% vs. 25.13% and 7.26% tail DNA in pre- and post-treatment protocols, respectively). The genoprotective effects may be ascribed to antioxidant potential and, possibly, to stimulation of DNA repair processes. The Moldavian Thymus species are valuable resources of bioactive EOs for pharmaceutical and food industries (T. vulgaris, T.calcareus) but also for flavor industry and perfumery (T. x citriodorus, T. citriodorus 'Aureus', T. vulgaris 'Faustini').
引用
收藏
页码:175 / 186
页数:12
相关论文
共 50 条
  • [1] The effects of anti-aspergillus essential oils and the site of their activities
    Minooeianhaghighi, M. H.
    Kosravi, A. R.
    MYCOSES, 2011, 54 : 63 - 64
  • [2] Chemical Composition of Essential Oils of Thymus and Mentha Species and Their Antifungal Activities
    Sokovic, Marina D.
    Vukojevic, Jelena
    Marin, Petar D.
    Brkic, Dejan D.
    Vajs, Vlatka
    van Griensven, Leo J. L. D.
    MOLECULES, 2009, 14 (01): : 238 - 249
  • [3] Chemical Composition and Antioxidant and Anticandidal Activities of Essential Oils from Different Wild Moroccan Thymus Species
    Jamali, Chaima Alaoui
    El Bouzidi, Laila
    Bekkouche, Khalid
    Lahcen, Hassani
    Markouk, Mohammed
    Wohlmuth, Hans
    Leach, David
    Abbad, Abdelaziz
    CHEMISTRY & BIODIVERSITY, 2012, 9 (06) : 1188 - 1197
  • [4] Chemical Composition, Antibacterial and Antioxidant Activities of the Essential Oils from Thymus satureioides and Thymus pallidus
    Ichrak, Ghalbane
    Rim, Belaqziz
    Loubna, Ait Said
    Khalid, Oufdou
    Abderrahmane, Romane
    Said, El Messoussi
    NATURAL PRODUCT COMMUNICATIONS, 2011, 6 (10) : 1507 - 1510
  • [5] Chemical composition, antioxidant and antimicrobial activities of essential oils obtained from wild and cultivated Moroccan Thymus species
    El Bouzidi, Laila
    Jamali, Chaima Alaoui
    Bekkouche, Khalid
    Hassani, Lahcen
    Wohlmuth, Hans
    Leach, David
    Abbad, Abdelaziz
    INDUSTRIAL CROPS AND PRODUCTS, 2013, 43 : 450 - 456
  • [6] Composition and in vitro Antimicrobial and Antioxidant Activities of the Essential Oils of Four Thymus Species in Turkey
    Azaz, A. D.
    Celen, S.
    ASIAN JOURNAL OF CHEMISTRY, 2012, 24 (05) : 2082 - 2086
  • [7] Composition of the essential oils of Thymus and Origanum species from Algeria and their antioxidant and antimicrobial activities
    Hazzit, Mohamed
    Baaliouamer, Aoumeur
    Faleiro, M. Leonor
    Miguel, M. Graca
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (17) : 6314 - 6321
  • [8] Composition and antioxidant activities of the essential oils of Thymus caespititius, Thymus camphoratus and Thymus mastichina
    Miguel, G
    Simoes, M
    Figueiredo, AC
    Barroso, JG
    Pedro, LG
    Carvalho, L
    FOOD CHEMISTRY, 2004, 86 (02) : 183 - 188
  • [9] Antigenotoxic and antioxidant activities of Pituranthos chloranthus essential oils
    Neffati, A.
    Bouhlel, I.
    Ben Sghaier, M.
    Boubaker, J.
    Limem, I.
    Kilani, S.
    Skandrani, I.
    Bhouri, W.
    Le Dauphin, J.
    Barillier, D.
    Mosrati, R.
    Chekir-Ghedira, L.
    Ghedira, K.
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2009, 27 (02) : 187 - 194