Anti-mycobacterial activities of copper(II) salicylaldimine complexes derived from long-chain aliphatic amines

被引：4
作者：
Patterson, Alyssa E. [1 ]
Bowes, Eric G. [1 ]
Bos, Allyson [2 ]
O'Neill, Taryn [2 ]
Li, Haoxin [2 ]
Flewelling, Andrew [2 ]
Vogels, Christopher M. [1 ]
Decken, Andreas [3 ]
Gray, Christopher A. [2 ]
Westcott, Stephen A. [1 ]
机构：
[1] Mt Allison Univ, Dept Chem & Biochem, Sackville, NB E4L 1G8, Canada
[2] Univ New Brunswick, Dept Biol, St John, NB E2L 4L5, Canada
[3] Univ New Brunswick, Dept Chem, Fredericton, NB E3B 5A3, Canada
来源：
CANADIAN JOURNAL OF CHEMISTRY | 2013年 / 91卷 / 11期
关键词：
aliphatic amines; anti-mycobacterial; copper; lipophilic; tuberculosis; SCHIFF-BASE LIGANDS; X-RAY-DIFFRACTION; BIOLOGICAL-ACTIVITY; MYCOBACTERIUM-TUBERCULOSIS; NICKEL(II); COBALT(II); BIDENTATE; PROTEINS; BINDING; DIMER;
D O I：
10.1139/cjc-2013-0274
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Twelve copper(II) Schiff base complexes derived from lipophilic amines have been prepared using either salicylaldehyde or ortho-vanillin via a microwave-assisted reaction. All complexes have been obtained elementally pure and an X-ray diffraction of an isopentyl derivative has confirmed the structure of these compounds. All complexes showed a promising degree of anti-mycobacterial activity against Mycobacterium tuberculosis, where activity seemed to increase with an increase in the length of the aliphatic chain.
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收藏
页码：1093 / 1097
页数：5
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