Diabetes Mellitus Itself Increases Cardio-Cerebrovascular Risk and Renal Complications in Primary Aldosteronism

被引：17

作者：

Saiki, Aya ^{[1
]}

Otsuki, Michio ^{[1
]}

Tamada, Daisuke ^{[1
]}

Kitamura, Tetsuhiro ^{[1
]}

Shimomura, Iichiro ^{[1
]}

Kurihara, Isao ^{[2
]}

Ichijo, Takamasa ^{[3
]}

Takeda, Yoshiyu ^{[4
]}

Katabami, Takuyuki ^{[5
]}

Tsuiki, Mika ^{[6
]}

Wada, Norio ^{[7
]}

Yanase, Toshihiko ^{[8
]}

Ogawa, Yoshihiro ^{[9
]}

Kawashima, Junji ^{[10
]}

Sone, Masakatsu ^{[11
]}

Inagaki, Nobuya ^{[11
]}

Yoshimoto, Takanobu ^{[12
,13
]}

Okamoto, Ryuji ^{[14
]}

Takahashi, Katsutoshi ^{[15
]}

Kobayashi, Hiroki ^{[16
]}

Tamura, Kouichi ^{[17
]}

Kamemura, Kohei ^{[18
]}

Yamamoto, Koichi ^{[19
]}

Izawa, Shoichiro ^{[20
]}

Kakutani, Miki ^{[21
]}

Yamada, Masanobu ^{[22
]}

Tanabe, Akiyo ^{[23
]}

Naruse, Mitsuhide ^{[6
,24
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Keio Univ, Sch Med, Dept Endocrinol Metab & Nephrol, Tokyo 1608582, Japan

[3] Saiseikai Yokohamashi Tobu Hosp, Dept Endocrinol & Metab, Yokohama, Kanagawa 2390012, Japan

[4] Kanazawa Univ, Grad Sch Med Sci, Dept Internal Med, Kanazawa, Ishikawa 9208640, Japan

[5] St Marianna Univ, Yokohama City Seibu Hosp, Dept Internal Med, Div Metab & Endocrinol,Sch Med, Yokohama, Kanagawa 2410811, Japan

[6] Natl Hosp Org Kyoto Med Ctr, Dept Endocrinol & Metab, Kyoto 6128555, Japan

[7] Sapporo City Gen Hosp, Dept Diabet & Endocrinol, Sapporo, Hokkaido 0608604, Japan

[8] Muta Hosp, Fukuoka 8140163, Japan

[9] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 8128582, Japan

[10] Kumamoto Univ, Fac Life Sci, Dept Metab Med, Kumamoto 8608556, Japan

[11] Kyoto Univ, Grad Sch Med, Dept Diabet Endocrinol & Nutr, Kyoto 6068507, Japan

[12] Tokyo Med & Dent Univ, Dept Mol Endocrinol & Metab, Tokyo 1138510, Japan

[13] Tokyo Metropolitan Hiroo Hosp Tokyo, Dept Diabet & Endocrinol, Tokyo 1500013, Japan

[14] Mie Univ Hosp, Dept Cardiol, Tsu, Mie 5148507, Japan

[15] Showa Gen Hosp, Div Metab, Tokyo 1878510, Japan

[16] Nihon Univ, Sch Med, Div Nephrol Hypertens & Endocrinol, Tokyo 1738610, Japan

[17] Yokohama City Univ, Grad Sch Med, Dept Med Sci & Cardiorenal Med, Yokohama, Kanagawa 2360004, Japan

[18] Shinko Hosp, Dept Cardiol, Kobe, Hyogo 6510072, Japan

[19] Osaka Univ, Grad Sch Med, Dept Geriatr & Gen Med, Suita, Osaka 5650871, Japan

[20] Tottori Univ Hosp, Dept Endocrinol & Metab, Yonago, Tottori 6838504, Japan

[21] Hyogo Coll Med, Dept Internal Med, Div Diabet Endocrinol & Clin Immunol, Nishinomiya, Hyogo 6638501, Japan

[22] Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, Japan

[23] Natl Ctr Global Hlth & Med, Div Endocrinol, Tokyo 1628655, Japan

[24] Ijinkai Takeda Gen Hosp, Endocrine Ctr, Kyoto 6011495, Japan

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2020年 / 105卷 / 07期

关键词：

primary aldosteronism; diabetes mellitus; cardio-cerebrovascular events; proteinuria; eGFR; PREVALENCE; OUTCOMES; MORTALITY; EVENTS; DAMAGE;

D O I：

10.1210/clinem/dgaa177

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context: The prevalence of diabetes mellitus (DM) in patients with primary aldosteronism (PA) is higher than in those with essential hypertension and the general population. Although DM is a common major risk factor for cardio cerebrovascular (CCV) diseases and renal complications, details of its effects in PA have not been demonstrated. Objective: The aim of this study was to determine the effects of coexistent DM on the risk of CCV events and progression of renal complications in PA patients. Design: A multi-institutional, cross-sectional study was conducted. Patients and Methods: PA patients experienced between January 2006 and October 2016 and with available data of CCV events and DM were enrolled from the Japan PA registry of the Japan Primary Aldosteronism Study/Japan Rare Intractable Adrenal Diseases Study (n = 2524). CCV events and renal complications were compared between a DM group and a non-DM group by logistic and liner-regression analysis. Results: DM significantly increased the odds ratio (OR) of CCV events (OR 1.59, 95% CI: 1.05-2.41) and that of proteinuria (OR 2.25, 95% CI: 1.59-3.16). DM correlated significantly with declines in estimated glomerular filtration rate (13 = .05, P = .02). Conclusions: This the first report to demonstrate the presence of DM as an independent risk factor for CCV events and renal complications, even in PA patients. Management of DM should be considered in addition to the specific treatment of PA.

引用

页码：E2531 / E2537

页数：7

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