Regulation of TGFβ in the immune system: An emerging role for integrins and dendritic cells

被引：92
作者：
Worthington, John J. [1 ,2 ]
Fenton, Thomas M. [1 ,2 ]
Czajkowska, Beata I. [1 ,2 ]
Klementowicz, Joanna E. [1 ,2 ]
Travis, Mark A. [1 ,2 ]
机构：
[1] Univ Manchester, Manchester Immunol Grp, Fac Life Sci, Manchester M13 9PT, Lancs, England
[2] Univ Manchester, Fac Life Sci, Wellcome Trust Ctr Cell Matrix Res, Manchester M13 9PT, Lancs, England
来源：
IMMUNOBIOLOGY | 2012年 / 217卷 / 12期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Adaptive immunity; Dendritic cell; Integrin; T-cell; TGF beta; GROWTH-FACTOR-BETA; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EPIDERMAL LANGERHANS CELLS; ALPHA-V-INTEGRINS; T-CELLS; ALPHA-V-BETA-8-MEDIATED ACTIVATION; RETINOIC-ACID; MICE; DIFFERENTIATION; EXPRESSION;
D O I：
10.1016/j.imbio.2012.06.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-beta (TGF-beta). TGF-beta is produced by and has effects on many different cells of the immune system, and plays fundamental roles in the regulation of immune responses during homeostasis, infection and disease. Although many cells can produce TGF beta, it is always produced as an inactive complex that must be activated to bind to the TGF beta receptor complex and promote downstream signalling. Thus, regulation of TGF beta activation is a crucial step in controlling TGF beta function. This review will discuss how TGF beta controls diverse immune responses and how TGF beta function is regulated, with a focus on recent work highlighting a critical role for the integrin alpha v beta 8 expressed by dendritic cells in activating TGF beta. (C) 2012 Elsevier GmbH. All rights reserved.
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收藏
页码：1259 / 1265
页数：7
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