Neuromuscular Diseases

被引:59
作者
Morrison, Brett M. [1 ]
机构
[1] Johns Hopkins Univ, Dept Neurol, 855 North Wolfe St,Rangos 248, Baltimore, MD 21205 USA
关键词
electromyography; myopathy; neuropathy; radiculopathy; ganglionopathy; amyotrophic lateral sclerosis; AMYOTROPHIC-LATERAL-SCLEROSIS; MULTIFOCAL MOTOR NEUROPATHY; BIOPSY;
D O I
10.1055/s-0036-1586263
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neuromuscular diseases are a broadly defined group of disorders that all involve injury or dysfunction of peripheral nerves or muscle. The site of injury can be in the cell bodies (i.e., amyotrophic lateral sclerosis [ALS] or sensory ganglionopathies), axons (i.e., axonal peripheral neuropathies or brachial plexopathies), Schwann cells (i.e., chronic inflammatory demyelinating polyradiculoneuropathy), neuromuscular junction (i.e., myasthenia gravis or Lambert-Eaton myasthenic syndrome), muscle (i.e., inflammatory myopathy or muscular dystrophy), or any combination of these sites. Some neuromuscular diseases are also associated with central nervous system disease, such as ALS, but most are restricted to the peripheral nervous system. The multitude of possible sites of injury can make neuromuscular diseases difficult to diagnose. Here the author reviews key features of the clinical presentation that help localize the site of injury and some basic tenets of electromyography. He then shares several pearls in diagnosing and treating patients with specific neuromuscular diseases.
引用
收藏
页码:409 / 418
页数:10
相关论文
共 21 条
[1]  
Arcila-Londono X, 2013, HAND CLINIC, V115, P429, DOI 10.1016/B978-0-444-52902-2.00024-2
[2]   A CONTROLLED TRIAL OF RILUZOLE IN AMYOTROPHIC-LATERAL-SCLEROSIS [J].
BENSIMON, G ;
LACOMBLEZ, L ;
MEININGER, V ;
BOUCHE, P ;
DELWAIDE, C ;
COURATIER, P ;
BLIN, O ;
VIADER, F ;
PEYROSTPAUL, H ;
DAVID, J ;
MALOTEAUX, JM ;
HUGON, J ;
LATERRE, EC ;
RASCOL, A ;
CLANET, M ;
VALLAT, JM ;
DUMAS, A ;
SERRATRICE, G ;
LECHEVALLIER, B ;
PEUCH, AJ ;
NGUYEN, T ;
SHU, C ;
BASTIEN, P ;
PAPILLON, C ;
DURRLEMAN, S ;
LOUVEL, E ;
GUILLET, P ;
LEDOUX, L ;
ORVOENFRIJA, E ;
DIB, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (09) :585-591
[3]   Needle electromyographic findings in 98 patients with myositis [J].
Blijham, Paul J. ;
Hengstman, Gerald J. D. ;
Hama-Amin, Ako Dara ;
van Engelen, Baziel G. M. ;
Zwarts, Machiel J. .
EUROPEAN NEUROLOGY, 2006, 55 (04) :183-188
[4]  
Ferrante Mark A, 2014, Continuum (Minneap Minn), V20, P1323, DOI 10.1212/01.CON.0000455878.60932.37
[5]   Non-length dependent small fibre neuropathy/ganglionopathy [J].
Gorson, K. C. ;
Herrmann, D. N. ;
Thiagarajan, R. ;
Brannagan, T. H. ;
Chin, R. L. ;
Kinsella, L. J. ;
Ropper, A. H. .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2008, 79 (02) :163-169
[6]   SENSORY NEURONOPATHIES [J].
Gwathmey, Kelly Graham .
MUSCLE & NERVE, 2016, 53 (01) :8-19
[7]   EVIDENCE FOR SALTATORY CONDUCTION IN PERIPHERAL MYELINATED NERVE FIBRES [J].
HUXLEY, AF ;
STAMPFLI, R .
JOURNAL OF PHYSIOLOGY-LONDON, 1949, 108 (03) :315-339
[8]   Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis [J].
Massman, PJ ;
Sims, J ;
Cooke, N ;
Haverkamp, LJ ;
Appel, V ;
Appel, SH .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1996, 61 (05) :450-455
[9]   GUILLAIN-BARRE DISEASE COMPLEX - A STATEMENT OF DIAGNOSTIC CRITERIA AND ANALYSIS OF 100 CASES [J].
MCFARLAND, HR ;
HELLER, GL .
ARCHIVES OF NEUROLOGY, 1966, 14 (02) :196-+
[10]   Update on the treatment of chronic inflammatory demyelinating polyradiculoneuropathy [J].
Nobile-Orazio, Eduardo ;
Gallia, Francesca .
CURRENT OPINION IN NEUROLOGY, 2015, 28 (05) :480-485