Immunoregulation by members of the TGFβ superfamily

被引：279
作者：
Chen, WanJun [1 ]
ten Dijke, Peter [2 ]
机构：
[1] Natl Inst Dent & Craniofacial Res, Mucosal Immunol Sect, NIH, Bethesda, MD 20892 USA
[2] Leiden Univ, Med Ctr, Canc Genom Ctr Netherlands, Dept Mol Cell Biol, Leiden, Netherlands
来源：
NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 12期
基金：
美国国家卫生研究院;
关键词：
GROWTH-FACTOR-BETA; BONE MORPHOGENETIC PROTEIN-6; CELL-DERIVED CYTOKINE; REGULATORY T-CELLS; FC FUSION PROTEIN; ACTIVIN-A; BINDING-PROTEIN; TARGETED DISRUPTION; SIGNALING PATHWAYS; DENDRITIC CELLS;
D O I：
10.1038/nri.2016.112
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The transforming growth factor-beta (TGF beta) superfamily is encoded by 33 genes and includes TGF beta, bone morphogenetic proteins (BMPs) and activins. Although TGF beta is well recognized as a crucial regulator of immune responses, the immunoregulatory functions of other TGF beta family members are less clear. However, recent evidence suggests that BMPs and activins have important roles in regulating immune responses. In this Review, we briefly outline the signalling pathways of the TGF beta superfamily and discuss new insights into the immunoregulatory functions of BMPs and activins in the context of infection, inflammation and cancer.
引用
收藏
页码：723 / 740
页数：18
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