Immunoregulation by members of the TGFβ superfamily

被引：284

作者：

Chen, WanJun ^{[1
]}

ten Dijke, Peter ^{[2
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Mucosal Immunol Sect, NIH, Bethesda, MD 20892 USA

[2] Leiden Univ, Med Ctr, Canc Genom Ctr Netherlands, Dept Mol Cell Biol, Leiden, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 12期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR-BETA; BONE MORPHOGENETIC PROTEIN-6; CELL-DERIVED CYTOKINE; REGULATORY T-CELLS; FC FUSION PROTEIN; ACTIVIN-A; BINDING-PROTEIN; TARGETED DISRUPTION; SIGNALING PATHWAYS; DENDRITIC CELLS;

D O I：

10.1038/nri.2016.112

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The transforming growth factor-beta (TGF beta) superfamily is encoded by 33 genes and includes TGF beta, bone morphogenetic proteins (BMPs) and activins. Although TGF beta is well recognized as a crucial regulator of immune responses, the immunoregulatory functions of other TGF beta family members are less clear. However, recent evidence suggests that BMPs and activins have important roles in regulating immune responses. In this Review, we briefly outline the signalling pathways of the TGF beta superfamily and discuss new insights into the immunoregulatory functions of BMPs and activins in the context of infection, inflammation and cancer.

引用

页码：723 / 740

页数：18

共 206 条

[71]

Huber S, 2011, CRIT REV IMMUNOL, V31, P53

[72] Activin A Promotes the TGF-β-Induced Conversion of CD4+CD25- T Cells into Foxp3+ Induced Regulatory T Cells [J].

Huber, Samuel ;

Stahl, Felix R. ;

Schrader, Joerg ;

Lueth, Stefan ;

Presser, Katrin ;

Carambia, Antonella ;

Flavell, Richard A. ;

Werner, Sabine ;

Blessing, Manfred ;

Herkel, Johannes ;

Schramm, Christoph .

JOURNAL OF IMMUNOLOGY, 2009, 182 (08) :4633-4640

[73] Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: Differential effects of BMP-6 and BMP-7 [J].

Huse, Kanutte ;

Bakkebo, Maren ;

Oksvold, Morten P. ;

Forfang, Lise ;

Hilden, Vera I. ;

Stokke, Trond ;

Smeland, Erlend B. ;

Myklebust, June H. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (11) :3135-3145

[74] Identification of Acvr2a as a Th17 Cell-Specific Gene Induced during Th17 Differentiation [J].

Ihn, Hyun-ju ;

Kim, Dong Hyeok ;

Oh, Sang-Seok ;

Moon, Chaerin ;

Chung, Jin Woong ;

Song, Hyunkeun ;

Kim, Kwang Dong .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2011, 75 (11) :2138-2141

[75] Truncated Form of TGF-βRII, But Not Its Absence, Induces Memory CD8+ T Cell Expansion and Lymphoproliferative Disorder in Mice [J].

Ishigame, Harumichi ;

Mosaheb, Munir M. ;

Sanjabi, Shomyseh ;

Flavell, Richard A. .

JOURNAL OF IMMUNOLOGY, 2013, 190 (12) :6340-6350

[76] Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis [J].

Ishigame, Harumichi ;

Zenewicz, Lauren A. ;

Sanjabi, Shomyseh ;

Licona-Limon, Paula ;

Nakayama, Maki ;

Leonard, Warren J. ;

Flavell, Richard A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (17) :6961-6966

[77] Negative regulation of TGF-β receptor/Smad signal transduction [J].

Itoh, Susumu ;

ten Dijke, Peter .

CURRENT OPINION IN CELL BIOLOGY, 2007, 19 (02) :176-184

[78] Activin A and TGF-β promote TH9 cell-mediated pulmonary allergic pathology [J].

Jones, Carla P. ;

Gregory, Lisa G. ;

Causton, Benjamin ;

Campbell, Gaynor A. ;

Lloyd, Clare M. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (04) :1000-U512

[79] Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia [J].

Jones, Kristian L. ;

Mansell, Ashley ;

Patella, Shane ;

Scott, Bernadette J. ;

Hedger, Mark P. ;

de Kretser, David M. ;

Phillips, David J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (41) :16239-16244

[80] Soluble betaglycan reduces renal damage progression in db/db mice [J].

Juarez, Patricia ;

Vilchis-Landeros, M. Magdalena ;

Ponce-Coria, Jose ;

Mendoza, Valentin ;

Hernandez-Pando, Rogelio ;

Bobadilla, Norma A. ;

Lopez-Casillas, Fernando .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2007, 292 (01) :F321-F329

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