Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naive Patients with Major Depression: A Study in the "Real World" Clinical Practice

被引：28

作者：

De Berardis, Domenico ^{[1
,2
]}

Olivieri, Luigi ^{[1
]}

Rapini, Gabriella ^{[1
]}

Di Natale, Serena ^{[1
]}

Serroni, Nicola ^{[1
]}

Fornaro, Michele ^{[3
,4
]}

Orsolini, Laura ^{[4
,5
]}

Valchera, Alessandro ^{[4
,6
]}

Carano, Alessandro ^{[7
]}

Vellante, Federica ^{[1
,2
]}

Varasano, Paola Annunziata ^{[8
]}

Pressanti, Gabriella Lucidi ^{[8
]}

Serafini, Gianluca ^{[9
]}

Pompili, Maurizio ^{[10
]}

Martinotti, Giovanni ^{[2
]}

Di Giannantonio, Massimo ^{[2
]}

机构：

[1] Hosp G Mazzini, Dept Mental Hlth, Psychiat Serv Diag & Treatment, Natl Hlth Serv, P Zza Italia 1, I-64100 Teramo, Italy

[2] Univ G DAnnunzio, Dept Neurosci & Imaging, Chieti, Italy

[3] Univ Naples Federico II, Dept Psychiat, Naples, Italy

[4] Polyedra, Teramo, Italy

[5] Univ Hertfordshire, Sch Life & Med Sci, Hatfield, Herts, England

[6] Hermanas Hosp, Villa S Giuseppe Hosp, Ascoli Piceno, England

[7] Hosp Madonna Del Soccorso, Psychiat Serv Diag & Treatment, Natl Hlth Serv, Dept Mental Hlth, San Benedetto Del Tronto, England

[8] G Mazzini Hosp, Dept Immunohematol & Transfus Med, Teramo, England

[9] Univ Genoa, Sect Psychiat, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

[10] Sapienza Univ Rome, St Andrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy

来源：

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | 2019年 / 17卷 / 02期

关键词：

Affective symptoms; Alexithymia; Depression; Suicidal ideation; Homocysteine; B-VITAMIN DEFICIENCY; BLOOD-BRAIN-BARRIER; PLASMA HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; SCHIZOPHRENIA; DISORDER; SCALE; HYPOTHESIS; METHIONINE; STRESS;

D O I：

10.9758/cpn.2019.17.2.318

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: This study was performed to elucidate relationships between alexithymia, suicide ideation and homocysteine levels in drug-naive outpatients with major depressive disorder (MDD). Methods: Sixty seven outpatients with MDD with melancholic features were evaluated by the means of the Hamilton Depression Rating Scale, the Toronto Alexithymia Scale (TAS-20), the Scale of Suicide Ideation, and homocysteine levels. Results: Alexithymic subjects showed higher scores on all scales and higher homocysteine levels. Regression analysis shown higher homocysteine levels and TAS-20' "Difficulty in Describing Feelings" dimension, in turn being associated with higher suicide ideation. Conclusion: In conclusion, alexithymic MDD outpatients may characterize for homocysteine dysregulation that may be linked to suicide ideation, regardless depression' severity. However, study limitations are discussed and must be considered.

引用

页码：318 / 322

页数：5

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