Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naive Patients with Major Depression: A Study in the "Real World" Clinical Practice

被引:28
作者
De Berardis, Domenico [1 ,2 ]
Olivieri, Luigi [1 ]
Rapini, Gabriella [1 ]
Di Natale, Serena [1 ]
Serroni, Nicola [1 ]
Fornaro, Michele [3 ,4 ]
Orsolini, Laura [4 ,5 ]
Valchera, Alessandro [4 ,6 ]
Carano, Alessandro [7 ]
Vellante, Federica [1 ,2 ]
Varasano, Paola Annunziata [8 ]
Pressanti, Gabriella Lucidi [8 ]
Serafini, Gianluca [9 ]
Pompili, Maurizio [10 ]
Martinotti, Giovanni [2 ]
Di Giannantonio, Massimo [2 ]
机构
[1] Hosp G Mazzini, Dept Mental Hlth, Psychiat Serv Diag & Treatment, Natl Hlth Serv, P Zza Italia 1, I-64100 Teramo, Italy
[2] Univ G DAnnunzio, Dept Neurosci & Imaging, Chieti, Italy
[3] Univ Naples Federico II, Dept Psychiat, Naples, Italy
[4] Polyedra, Teramo, Italy
[5] Univ Hertfordshire, Sch Life & Med Sci, Hatfield, Herts, England
[6] Hermanas Hosp, Villa S Giuseppe Hosp, Ascoli Piceno, England
[7] Hosp Madonna Del Soccorso, Psychiat Serv Diag & Treatment, Natl Hlth Serv, Dept Mental Hlth, San Benedetto Del Tronto, England
[8] G Mazzini Hosp, Dept Immunohematol & Transfus Med, Teramo, England
[9] Univ Genoa, Sect Psychiat, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy
[10] Sapienza Univ Rome, St Andrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy
关键词
Affective symptoms; Alexithymia; Depression; Suicidal ideation; Homocysteine; B-VITAMIN DEFICIENCY; BLOOD-BRAIN-BARRIER; PLASMA HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; SCHIZOPHRENIA; DISORDER; SCALE; HYPOTHESIS; METHIONINE; STRESS;
D O I
10.9758/cpn.2019.17.2.318
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective: This study was performed to elucidate relationships between alexithymia, suicide ideation and homocysteine levels in drug-naive outpatients with major depressive disorder (MDD). Methods: Sixty seven outpatients with MDD with melancholic features were evaluated by the means of the Hamilton Depression Rating Scale, the Toronto Alexithymia Scale (TAS-20), the Scale of Suicide Ideation, and homocysteine levels. Results: Alexithymic subjects showed higher scores on all scales and higher homocysteine levels. Regression analysis shown higher homocysteine levels and TAS-20' "Difficulty in Describing Feelings" dimension, in turn being associated with higher suicide ideation. Conclusion: In conclusion, alexithymic MDD outpatients may characterize for homocysteine dysregulation that may be linked to suicide ideation, regardless depression' severity. However, study limitations are discussed and must be considered.
引用
收藏
页码:318 / 322
页数:5
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