Role of Azoles in Cancer Prevention and Treatment: Present and Future Perspectives

被引：28

作者：

Ahmad, Khurshid ^{[1
]}

Khan, Mohd Kalim A. ^{[2
]}

Baig, Mohammad Hassan ^{[3
]}

Imran, Mohd ^{[4
]}

Gupta, Girish Kumar ^{[5
]}

机构：

[1] Natl Bur Agriculturally Important Microorganisms, Mau Nath Bhanjan 275103, Uttar Pradesh, India

[2] Integral Univ, Dept Bioengn, Lucknow 226026, Uttar Pradesh, India

[3] Yeungnam Univ, Dept Med Biotechnol, Gyongsan, South Korea

[4] Inst Cytol & Prevent Oncol ICMR, Bioinformat Div, Noida, UP, India

[5] Maharishi Markandeshwar Univ, MM Coll Pharm, Dept Pharmaceut Chem, Ambala 133207, Haryana, India

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 01期

关键词：

Azoles; cancer; treatment; prevention; anti-HIV; derivatives; FACTOR-KAPPA-B; CONVERTING-ENZYME-INHIBITORS; TUMOR-NECROSIS-FACTOR; CELL-CYCLE ARREST; HEPATITIS-C VIRUS; BREAST-CANCER; BIOLOGICAL EVALUATION; BENZOTRIAZOLE DERIVATIVES; CLINICAL PHARMACOKINETICS; ANTICANCER ACTIVITY;

D O I：

10.2174/1871520616666161221112042

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Cancer has gradually become one of the leading causes of death worldwide. The incidence of cancer among the population has increased alarmingly over the last two decades, primarily due to an increasing population of immune-compromised patients and the continuing rise in anti-cancer drug resistance. Azole found privileged structure in medicinal chemistry and pharmaceutical industry and also found to be showing antioxidant; antimicrobial, anthelmintic, anticancer, antiviral, anti-parasitic, anti-inflammatory, anti-HIV, and antihypertensive activities. Objective: In this review, we highlight some areas of current interest in context to azoles and their derivatives as potential chemotherapeutic agents and inhibitors. Method: A comprehensive literature search was performed for writing this review. An updated view on different derivatives of azoles and use in cancer management has been discussed. Results: Here we have discussed the present scenario of azoles and their derivatives as potential chemotherapeutic agents and inhibitors. Along with, the future perspectives of azoles in cancer prevention and treatment are also discussed. Conclusion: The information provided in this review might be useful to researchers in designing of novel and potent multifunctional azole analogues for the treatment of cancer and other multifactorial diseases.

引用

页码：46 / 56

页数：11

共 130 条

[1] Status of hepatitis C virus vaccination: Recent update [J].

Abdelwahab, Kouka Saadeldin ;

Said, Zeinab Nabil Ahmed .

WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (02) :862-873

[2]

Acharya P. C., 2014, RES REV J DRUG DES D, V1, P13

[3]

Adinolfi B, 2015, ANTICANCER RES, V35, P3781

[4] Molecular targets of dietary agents for prevention and therapy of cancer [J].

Aggarwal, BB ;

Shishodia, S .

BIOCHEMICAL PHARMACOLOGY, 2006, 71 (10) :1397-1421

[5] Nuclear factor-κ-B:: The enemy within [J].

Aggarwal, BB .

CANCER CELL, 2004, 6 (03) :203-208

[6] Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts [J].

Ahmed, Salahuddin ;

Riegsecker, Sharayah ;

Beamer, Maria ;

Rahman, Ayesha ;

Bellini, Joseph V. ;

Bhansali, Pravin ;

Tillekeratne, L. M. Viranga .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 270 (02) :87-96

[7]

Al-Khodairy F. M., 2013, AM J BIOINFORMATICS, V3, P62, DOI [DOI 10.5923/J.BIOINFORMATICS.20130303.03, https://doi.org/10.5923/j.bioinformatics.20130303.03]

[8] Zidovudine use but not weight-based ribavirin dosing impacts anaemia during HCV treatment in HIV-infected persons [J].

Alvarez, D. ;

Dieterich, D. T. ;

Brau, N. ;

Moorehead, L. ;

Ball, L. ;

Sulkowski, M. S. .

JOURNAL OF VIRAL HEPATITIS, 2006, 13 (10) :683-689

[9]

[Anonymous], 2015, TOP DRUGS HIST PHARM

[10]

Arif J. M., 2011, BIOMIRR, V2, P1

← 1 2 3 4 5 6 7 8 9 10 →