Modeling epilepsy with pluripotent human cells

被引：16
作者：
Muotri, Alysson Renato [1 ,2 ]
机构：
[1] Univ Calif San Diego, Sch Med, Dept Pediat, Div Genet,VCSD Stem Cell Initiat, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Sch Med, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
来源：
EPILEPSY & BEHAVIOR | 2009年 / 14卷
关键词：
Epilepsy; Seizures; Human embryonic stem cells; Induced pluripotent stem cells; System biology; Chimeric brain; TEMPORAL-LOBE EPILEPSY; EMBRYONIC STEM-CELLS; DENTATE GYRUS; INDUCED NEUROGENESIS; NEURONS; SEIZURES; DIFFERENTIATION; REORGANIZATION; SPECIFICATION; GENERATION;
D O I：
10.1016/j.yebeh.2008.09.021
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Pluripotency is generally defined by the ability to differentiate into cell types representing all three germ layers: ectoderm, mesoderm, and endoderm. Human Pluripotent stem cells hold great promise in regenerative medicine and in cell replacement therapies because of their ability to self-renew and their developmental potential to become all cell types in the body. Moreover, pluripotent cells represent a unique system in which to study the normal development of the human nervous system and the several instances where the process may fail. Here, I propose several strategies for how Pluripotent stem cells, both human embryonic stem cells and induced pluripotent stem cells, can potentially be used to gain insights into the biology of temporal lobe epilepsy. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：81 / 85
页数：5
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