Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene

被引：68

作者：

Kai, M ^{[1
]}

Matsuoka, M ^{[1
]}

Nakata, N ^{[1
]}

Maeda, S ^{[1
]}

Gidoh, M ^{[1
]}

Maeda, Y ^{[1
]}

Hashimoto, K ^{[1
]}

Kobayashi, K ^{[1
]}

Kashiwabara, Y ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Leprosy Res Ctr, Higashimurayama, Tokyo 1890002, Japan

来源：

FEMS MICROBIOLOGY LETTERS | 1999年 / 177卷 / 02期

关键词：

chemotherapy; leprosy; genetic mutation; drug resistance;

D O I：

10.1111/j.1574-6968.1999.tb13737.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleo tide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homologous site has been reported in other bacteria, the mutation at residue 53 is the first case in bacteria. This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：231 / 235

页数：5

共 20 条

[1] Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase [J].

Achari, A ;

Somers, DO ;

Champness, JN ;

Bryant, PK ;

Rosemond, J ;

Stammers, DK .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (06) :490-497

[2] INITIATION OF PROTEIN-SYNTHESIS WITHOUT FORMYLATION IN A MUTANT OF ESCHERICHIA-COLI THAT GROWS IN ABSENCE OF TETRAHYDROFOLATE [J].

BAUMSTARK, BR ;

SPREMULLI, LL ;

RAJBHANDARY, UL ;

BROWN, GM .

JOURNAL OF BACTERIOLOGY, 1977, 129 (01) :457-471

[3]

delaCruz E, 1996, INT J LEPROSY, V64, P253

[4] CLONING AND SEQUENCE DETERMINATION OF THE GENE CODING FOR THE ELONGATION-FACTOR TU OF MYCOBACTERIUM-LEPRAE [J].

DHANDAYUTHAPANI, S ;

BANU, MJ ;

KASHIWABARA, Y .

JOURNAL OF BIOCHEMISTRY, 1994, 115 (04) :664-669

[5] Adaptation to sulfonamide resistance in Neisseria meningitidis may have required compensatory changes to retain enzyme function: Kinetic analysis of dihydropteroate synthases from N-meningitidis expressed in a knockout mutant of Escherichia coli [J].

Fermer, C ;

Swedberg, G .

JOURNAL OF BACTERIOLOGY, 1997, 179 (03) :831-837

[6] SULFONAMIDE RESISTANCE IN NEISSERIA-MENINGITIDIS AS DEFINED BY SITE-DIRECTED MUTAGENESIS COULD HAVE ITS ORIGIN IN OTHER SPECIES [J].

FERMER, C ;

KRISTIANSEN, BE ;

SKOLD, O ;

SWEDBERG, G .

JOURNAL OF BACTERIOLOGY, 1995, 177 (16) :4669-4675

[7]

Grosset J, 1984, Med Trop (Mars), V44, P17

[8]

HASTINGS RC, 1977, P SOC EXP BIOL MED, V156, P544, DOI 10.3181/00379727-156-39976

[9]

NAKAMURA M, 1994, JPN J LEPR, V64, P47

[10] IMPROVED TOOLS FOR BIOLOGICAL SEQUENCE COMPARISON [J].

PEARSON, WR ;

LIPMAN, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) :2444-2448

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