Gastroprotective effect of the aqueous leaf extract of Guiera senegalensis in Albino rats

被引：14
|
作者：
Akuodor, G. C. [1 ]
Essien, A. D. [1 ]
David-Oku, E. [2 ]
Chilaka, K. C. [3 ]
Akpan, J. L. [4 ]
Ezeokpo, B. [4 ]
Ezeonwumelu, J. O. C. [5 ]
机构：
[1] Univ Calabar, Coll Med Sci, Dept Pharmacol, Calabar, Nigeria
[2] Univ Calabar, Dept Biochem, Calabar, Nigeria
[3] Nnamdi Azikiwe Univ, Coll Hlth Sci, Dept Pharmacol & Therapeut, Awka, Nigeria
[4] Ebonyi State Univ, Fac Clin Med, Dept Pharmacol & Therapeut, Abakaliki, Nigeria
[5] Kampala Int Univ, Sch Pharm, Ishako Buchenyi, Uganda
来源：
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2013年 / 6卷 / 10期
关键词：
Guiera senegalensis; Aqueous extract; Ethanol; Aspirin; Stress induced gastric ulcers; ANTIULCER; KOLAVIRON;
D O I：
10.1016/S1995-7645(13)60136-4
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objective: To evaluate the effect of aqueous leaf extract of Guiera senegalensis (G. senegalensis) on gastric mucosal damage using different ulcer models. Methods: Considering the above claims, the present study was undertaken to validate the gastroprotective potential of the aqueous leaf extract of this plant against ethanol, water immersion and Aspirin induced ulcer models. Results: The leaf extract (50, 100 and 200 mg/kg, p.o.) significantly (P<0.05) decreased the ulcer index in all assays used. Conclusions: The results obtained, provide strong evidence of antiulcer activity of the leaf extract of G. senegalensis and support the traditional uses of the plant for the treatment of ulcer.
引用
收藏
页码：771 / 775
页数：5
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