Palladium-Catalyzed Oxidative Insertion of Carbon Monoxide to N-Sulfonyl-2-aminobiaryls through C-H Bond Activation: Access to Bioactive Phenanthridinone Derivatives in One Pot

被引：123

作者：

Rajeshkumar, Venkatachalam ^{[1
]}

Lee, Tai-Hua ^{[1
]}

Chuang, Shih-Ching ^{[1
]}

机构：

[1] Natl Chiao Tung Univ, Dept Appl Chem, Hsinchu 30010, Taiwan

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 07期

关键词：

REGIOSELECTIVE SYNTHESIS; CARBONYLATION REACTIONS; CHEMICAL-CONSTITUENTS; C(SP(3))-H BONDS; ARYL HALIDES; ALKALOIDS; CYCLIZATION; C(SP(2))-H; HIPPADINE; ALKENES;

D O I：

10.1021/ol4001922

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed oxidative carbonylation of N-sulfonyl-2-aminobiaryls through C-H bond activation and C-C, C-N bond formation under TFA-free and milder conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important phenanthrldlnone derivatives in yields up to 94%.

引用

页码：1468 / 1471

页数：4

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