Won't you come on in? How to favor lymphocyte infiltration in tumors

被引：15

作者：

Bellone, Matteo ^{[1
,3
]}

Calcinotto, Arianna ^{[1
,3
,4
]}

Corti, Angelo ^{[1
,2
,3
]}

机构：

[1] Ist Sci San Raffaele, Cellular Immunol Unit, I-20132 Milan, Italy

[2] Ist Sci San Raffaele, Tumor Biol & Vasc Targeting Unit, I-20132 Milan, Italy

[3] Ist Sci San Raffaele, Program Immunol Gene Therapy & Bioimmunotherapy C, I-20132 Milan, Italy

[4] Univ Vita Salute San Raffaele, Milan, Italy

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 06期

关键词：

tumor; T cells; immunotherapy; cell trafficking; endothelial cells; IMMUNOTHERAPY; CANCER; ANGIOGENESIS; VASCULATURE; THERAPY;

D O I：

10.4161/onci.20213

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cells, thereby enhancing the efficacy of active and adoptive immunotherapy.

引用

收藏

页码：986 / 988

页数：3

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