Won't you come on in? How to favor lymphocyte infiltration in tumors

被引：15
作者：
Bellone, Matteo [1 ,3 ]
Calcinotto, Arianna [1 ,3 ,4 ]
Corti, Angelo [1 ,2 ,3 ]
机构：
[1] Ist Sci San Raffaele, Cellular Immunol Unit, I-20132 Milan, Italy
[2] Ist Sci San Raffaele, Tumor Biol & Vasc Targeting Unit, I-20132 Milan, Italy
[3] Ist Sci San Raffaele, Program Immunol Gene Therapy & Bioimmunotherapy C, I-20132 Milan, Italy
[4] Univ Vita Salute San Raffaele, Milan, Italy
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 06期
关键词：
tumor; T cells; immunotherapy; cell trafficking; endothelial cells; IMMUNOTHERAPY; CANCER; ANGIOGENESIS; VASCULATURE; THERAPY;
D O I：
10.4161/onci.20213
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cells, thereby enhancing the efficacy of active and adoptive immunotherapy.
引用
收藏
页码：986 / 988
页数：3
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