Obstructive sleep apnea might trigger acute pulmonary embolism: results from a cohort study

被引：17

作者：

Berghaus, T. M. ^{[1
]}

Witkowska, A. ^{[1
]}

Wagner, T. ^{[1
]}

Faul, C. ^{[1
]}

Schwaiblmair, M. ^{[1
]}

von Scheidt, W. ^{[1
]}

机构：

[1] Univ Munich, Klinikum Augsburg, Dept Cardiol Resp Med & Intens Care, Stenglinstr 2, D-86156 Augsburg, Germany

来源：

CLINICAL RESEARCH IN CARDIOLOGY | 2016年 / 105卷 / 11期

关键词：

Pulmonary embolism; Symptom onset; Sleepdisordered breathing; Day-night pattern; POSITIVE AIRWAY PRESSURE; PLATELET ACTIVATION; SEVERITY;

D O I：

10.1007/s00392-016-1002-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obstructive sleep apnea (OSA) might be an independent risk factor for acute pulmonary embolism (APE). A prospective cohort study was conducted to investigate if APE is sleep-related in untreated OSA syndrome or not. 206 APE patients were evaluated by portable monitoring and polysomnography. APE symptoms which caused an arousal from sleep or occurred within the first hour after wake-up were considered to be sleep-related. APE manifestation is significantly more often sleep-related in patients with moderate or severe OSA compared to subjects with an apnea-hypopnea index aecurrency sign15/h (p < 0.001). The relative risk of sleep-related APE increases with the severity of OSA. OSA might trigger APE, possibly reflecting a pathophysiological relationship between these two conditions.

引用

页码：938 / 943

页数：6

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