Efficient synthesis and in vitro antifungal activity of 1H-benzimidazol-1-yl acetates/propionates containing 1H-1,2,4-triazole moiety

被引:32
作者
Zhang, Pei Zhi [1 ]
Zhou, Shao Fang [1 ]
Li, Tian Ren [1 ]
Jiang, Lin [1 ]
机构
[1] Shandong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China
关键词
Benzoimidazole; 1,2,4-Triazole; Synthesis; Antifungal activity; DERIVATIVES; DESIGN;
D O I
10.1016/j.cclet.2012.10.024
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A series of novel 1H-benzimidazol-1-yl acetates and 1H-benzimidazol-1-yl propionates containing 1H-1,2,4-triazole moiety were synthesized under microwave irradiation by multi-step reactions, in yields of 87-94%. Their in vitro antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum were evaluated by mycelial growth rate method. All the target compounds exhibit high activities against B. cinerea with the EC50 values of 7.96-21.74 mu g/mL, higher than that of carbendazim. (C) 2012 Lin Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码:1381 / 1384
页数:4
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