Antidote treatment for cyanide poisoning with hydroxocobalamin causes bright pink discolouration and chemical-analytical interferences

被引：6

作者：

Brunel, C. ^{[1
]}

Widmer, C. ^{[1
]}

Augsburger, M. ^{[1
]}

Dussy, F. ^{[2
]}

Fracasso, T. ^{[1
]}

机构：

[1] Hop Univ Geneve, Ctr Univ Romand Med Legale, CH-1211 Geneva, Switzerland

[2] Inst Legal Med, CH-4056 Basel, Switzerland

来源：

FORENSIC SCIENCE INTERNATIONAL | 2012年 / 223卷 / 1-3期

关键词：

Cyanide poisoning; Hydroxocobalamin; Antidote; Hypostasis discolouration; Bright pink discolouration; GAS-CHROMATOGRAPHY; MASS SPECTROMETRY; SMOKE-INHALATION; BLOOD CYANIDE; INGESTION;

D O I：

10.1016/j.forsciint.2012.08.019

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Here we report the case of a 70-year-old woman who committed suicide by cyanide poisoning. During resuscitation cares, she underwent an antidote treatment by hydroxocobalamin. Postmortem investigations showed marked bright pink discolouration of organs and fluids, and a lethal cyanide blood concentration of 43 mg/L was detected by toxicological investigation. Discolouration of hypostasis and organs has widely been studied in forensic literature. In our case, we interpreted the unusual pink coloration as the result of the presence of hydroxocobalamin. This substance is a known antidote against cyanide poisoning, indicated because of its efficiency and poor adverse effects. However, its main drawback is to interfere with measurements of many routine biochemical parameters. We have tested the potential influence of this molecule in some routine postmortem investigations. The results are discussed. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E10 / E12

页数：3

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