Facile Preparation of α-Aryl Nitriles by Direct Cyanation of Alcohols with TMSCN Under the Catalysis of InX3

被引：83

作者：

Chen, Gang ^{[1
]}

Wang, Zheng ^{[1
]}

Wu, Jiang ^{[1
]}

Ding, Kuiling ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 20期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/ol801812a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and efficient synthesis of alpha-aryl nitriles was developed by direct cyanation of alcohols with TMSCN under the catalysis of Lewis acid. Using 5-10 mol % of InBr3 as the catalyst, a variety of benzylic alcohols can be converted to the corresponding nitriles in 5-30 min with yields of 46-99%.

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收藏

页码：4573 / 4576

页数：4

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