Facile Preparation of α-Aryl Nitriles by Direct Cyanation of Alcohols with TMSCN Under the Catalysis of InX3

被引：82
作者：
Chen, Gang [1 ]
Wang, Zheng [1 ]
Wu, Jiang [1 ]
Ding, Kuiling [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 20期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1021/ol801812a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and efficient synthesis of alpha-aryl nitriles was developed by direct cyanation of alcohols with TMSCN under the catalysis of Lewis acid. Using 5-10 mol % of InBr3 as the catalyst, a variety of benzylic alcohols can be converted to the corresponding nitriles in 5-30 min with yields of 46-99%.
引用
收藏
页码：4573 / 4576
页数：4
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