Effect of Flavan-3-ols on the Adhesion of Potential Probiotic Lactobacilli to Intestinal Cells

被引：70

作者：

Bustos, Irene ^{[1
]}

Garcia-Cayuela, Tomas ^{[1
]}

Hernandez-Ledesma, Blanca ^{[1
]}

Pelaez, Carmen ^{[1
]}

Requena, Teresa ^{[1
]}

Carmen Martinez-Cuesta, M. ^{[1
]}

机构：

[1] CEI UAM CSIC, CIAL CSIC UAM, Inst Invest Ciencias Alimentac, Dept Biotechnol & Microbiol, Madrid 28049, Spain

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2012年 / 60卷 / 36期

关键词：

polyphenols; flavan-3-ols; lactobacilli; adhesion; IN-VITRO; MICROBIAL-METABOLISM; EPITHELIAL-CELL; GREEN TEA; CACO-2; POLYPHENOLS; MICROFLORA; BINDING; DERIVATIVES; INDUCTION;

D O I：

10.1021/jf301133g

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The effect of dietary flavan-3-ols on the adhesion of potential probiotic lactobacilli strains to intestinal cells was unraveled. The inhibitory activity of these compounds on intestinal cells was highlighted. The cytotoxic effect was shown to depend on both the compound's chemical structure (galloylation and polymerization) and degree of differentiation of intestinal cells. The effect of flavan-3-ols on bacteria adhesion differed greatly between compounds, strains, and intestinal cells. All flavan-3-ols inhibited significantly Lactobacillus acidophilus LA-5 and Lactobacillus plantarum IFPL379 adhesion except epigallocatechin gallate, which enhanced L. acidophilus LA-5 adhesion to Caco-2. Procyanidins B1 and B2 increased remarkably the adhesion of Lactobacillus casei LC115 to HT-29 cells, whereas epigallocatechin increased L. casei LC115 adhesion to Caco-2. These data showed the potential of flavan-3-ols to alter gut microecology by modifying adhesion of lactobacilli strains to intestinal cells.

引用

页码：9082 / 9088

页数：7

共 48 条

[1] Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines [J].