Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning

被引:43
作者
Andreska, Thomas [1 ]
Rauskolbb, Stefanie [1 ]
Schukraft, Nina [1 ]
Lueningschror, Patrick [1 ]
Sasi, Manju [1 ]
Signoret-Genest, Jeremy [1 ]
Behringer, Marcus [2 ]
Blum, Robert [1 ]
Sauer, Markus [2 ]
Tovote, Philip [1 ]
Sendtner, Michael [1 ]
机构
[1] Univ Hosp Wuerzburg, Inst Clin Neurobiol, D-97080 Wurzburg, Germany
[2] Julius Maximilians Univ Wuerzburg, Dept Biotechnol & Biophys, D-97074 Wurzburg, Germany
关键词
BDNF; motor cortex; motor learning; neurotrophic factor; striatum; LONG-TERM POTENTIATION; NERVE GROWTH-FACTOR; FACTOR MESSENGER-RNA; NEUROTROPHIC FACTOR; SYNAPTIC PLASTICITY; BASAL GANGLIA; MUSICAL MEMORY; UP-REGULATION; LATE-PHASE; BRAIN;
D O I
10.1523/JNEUROSCI.0288-20.2020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Motor learning depends on synaptic plasticity between corticostriatal projections and striatal medium spiny neurons. Retrograde tracing from the dorsolateral striatum reveals that both layer II/III and V neurons in the motor cortex express BDNF as a potential regulator of plasticity in corticostriatal projections in male and female mice. The number of these BDNF-expressing cortical neurons and levels of BDNF protein are highest in juvenile mice when adult motor patterns are shaped, while BDNF levels in the adult are low. When mice are trained by physical exercise in the adult, BDNF expression in motor cortex is reinduced, especially in layer II/III projection neurons. Reduced expression of cortical BDNF in 3-month-old mice results in impaired motor learning while space memory is preserved. These findings suggest that activity regulates BDNF expression differentially in layers II/III and V striatal afferents from motor cortex and that cortical BDNF is essential for motor learning.
引用
收藏
页码:6289 / 6308
页数:20
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