Unlocking the dysplasia puzzle

被引：1

作者：

Abboud, Camille N. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63130 USA

来源：

BLOOD | 2008年 / 112卷 / 08期

关键词：

D O I：

10.1182/blood-2008-06-160655

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Zhou and colleagues describe preclinical results in vitro and in vivo, showing constitutive TGF-beta activation in MDS and enhanced hematopoiesis following inhibition of TBRI kinase in MDS.

引用

页码：3005 / 3006

页数：4

共 8 条

[1] Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: Evidence for a role in apoptosis [J].

Briggs, Robert C. ;

Shults, Keith E. ;

Flye, Leanne A. ;

McClintock-Treep, Sara A. ;

Jagasia, Madan H. ;

Goodman, Stacey A. ;

Boulos, Fouad I. ;

Jacobberger, James W. ;

Stelzer, Greg T. ;

Head, David R. .

CANCER RESEARCH, 2006, 66 (09) :4645-4651

[2] DNA methylation profiling of myelodysplastic syndrome hematopoietic progenitor cells during in vitro lineage-specific differentiation [J].

Hopfer, Olaf ;

Komor, Martina ;

Koehler, Ina Sabine ;

Schulze, Matthias ;

Hoelzer, Dieter ;

Thiel, Eckhard ;

Hofmann, Wolf-Karsten .

EXPERIMENTAL HEMATOLOGY, 2007, 35 (05) :712-723

[3] Megakaryocytic dysfunction in myelodysplastic syndromes and idiopathic thrombocytopenic purpura is in part due to different forms of cell death [J].

Houwerzijl, E. J. ;

Blom, N. R. ;

van der Want, J. J. L. ;

Vellenga, E. ;

de Wolf, J. T. M. .

LEUKEMIA, 2006, 20 (11) :1937-1942

[4] Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function [J].

Marcondes, A. Mario ;

Mhyre, Andrew J. ;

Stirewalt, Derek L. ;

Kim, Soo-Hyun ;

Dinarello, Charles A. ;

Deeg, H. Joachim .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (08) :2865-2870

[5] Myelodysplastic syndromes [J].

Nimer, Stephen D. .

BLOOD, 2008, 111 (10) :4841-4851

[6]

Tang JH, 1997, J IMMUNOL, V159, P117

[7] Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes [J].

Tauro, S ;

Hepburn, MD ;

Peddie, CM ;

Bowen, DT ;

Pippard, MJ .

LEUKEMIA, 2002, 16 (05) :785-790

[8] p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure [J].

Zhou, Li ;

Opalinska, Joanna ;

Verma, Amit .

CELL CYCLE, 2007, 6 (05) :534-537

← 1 →