Ring-Closing Metathesis/Isomerization/Pictet-Spengler Cascade via Ruthenium/Chiral Phosphoric Acid Sequential Catalysis

被引：108

作者：

Cai, Quan ^{[1
]}

Liang, Xiao-Wei ^{[1
]}

Wang, Shou-Guo ^{[1
]}

Zhang, Jun-Wei ^{[1
]}

Zhang, Xiao ^{[1
]}

You, Shu-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 19期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE BRONSTED ACID; BIOMIMETIC ASYMMETRIC HYDROGENATION; NONREARRANGED MONOTERPENOID UNIT; ACYLIMINIUM CYCLIZATION CASCADES; SIMPLE INDOLE ALKALOIDS; PICTET-SPENGLER; RELAY CATALYSIS; BINARY-SYSTEM; COOPERATIVE CATALYSIS; 3-COMPONENT REACTIONS;

D O I：

10.1021/ol302215u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral phosphoric acid worked together with Hoveyda-Grubbs II catalyst enabling highly efficient synthesis of enantioenriched tetrahydro-beta-carbolines (up to 98% yield, 99% ee) through a ring-closing metathesis/isomerization/Pictet-Spengler cascade reaction via sequential catalysis.

引用

页码：5022 / 5025

页数：4

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