Ring-Closing Metathesis/Isomerization/Pictet-Spengler Cascade via Ruthenium/Chiral Phosphoric Acid Sequential Catalysis

被引：107
作者：
Cai, Quan [1 ]
Liang, Xiao-Wei [1 ]
Wang, Shou-Guo [1 ]
Zhang, Jun-Wei [1 ]
Zhang, Xiao [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 19期
基金：
中国国家自然科学基金;
关键词：
ENANTIOSELECTIVE BRONSTED ACID; BIOMIMETIC ASYMMETRIC HYDROGENATION; NONREARRANGED MONOTERPENOID UNIT; ACYLIMINIUM CYCLIZATION CASCADES; SIMPLE INDOLE ALKALOIDS; PICTET-SPENGLER; RELAY CATALYSIS; BINARY-SYSTEM; COOPERATIVE CATALYSIS; 3-COMPONENT REACTIONS;
D O I：
10.1021/ol302215u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chiral phosphoric acid worked together with Hoveyda-Grubbs II catalyst enabling highly efficient synthesis of enantioenriched tetrahydro-beta-carbolines (up to 98% yield, 99% ee) through a ring-closing metathesis/isomerization/Pictet-Spengler cascade reaction via sequential catalysis.
引用
收藏
页码：5022 / 5025
页数：4
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