Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis

被引：64

作者：

Tsuji, MH

Yanagawa, T

Iwasa, S

Tabuchi, K

Onizawa, K

Bannai, S

Toyooka, H

Yoshida, H

机构：

[1] Univ Tsukuba, Inst Clin Med, Dept Oral & Maxillofacial Surg, Tsukuba, Ibaraki 3058575, Japan

[2] Univ Tsukuba, Dept Anesthesiol, Tsukuba, Ibaraki 3058575, Japan

[3] Univ Tsukuba, Dept Pathol, Tsukuba, Ibaraki 3058575, Japan

[4] Osaka Univ, Sch Med, Biomed Res Ctr, Dept Neuroanat, Osaka 5650871, Japan

[5] Univ Tsukuba, Inst Basic Sci, Dept Biochem, Tsukuba, Ibaraki 3058575, Japan

来源：

CANCER LETTERS | 1999年 / 138卷 / 1-2期

关键词：

heat shock protein; heme oxygenase; immunohistochemistry; squamous cell carcinoma; oral cancer;

D O I：

10.1016/S0304-3835(98)00372-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thirty-eight oral squamous cell carcinomas (SCCs) were semi-quantitatively analyzed by immunohistochemical staining, and the relation between heme oxygenase-1 (HO-1) expression and the clinical status were correlated. High immunostaining of HO-1 was detected in lymph node metastasis negative groups (P = 0.0018) and in well-differentiated SCCs (P = 0.0016). There were no significant correlations between heme oxygenase-1 expression and other factors, such as size of the tumor, staging, age and sex. These findings further support the proposition that high heme oxygenase-1 expression in oral SCCs can be useful in identifying patients at low risk of lymph node metastasis. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：53 / 59

页数：7

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