Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70

被引：20
|
作者：
Vu, CB [1 ]
Corpuz, EG [1 ]
Pradeepan, SG [1 ]
Violette, S [1 ]
Bartlett, C [1 ]
Sawyer, TK [1 ]
机构：
[1] ARIAD Pharmaceut Inc, Cambridge, MA 02139 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 20期
关键词：
D O I：
10.1016/S0960-894X(99)00524-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of a series of 1,2,4-oxadiazole analogs is discussed along with their ZAP-70 SH2 inhibitory activity. The tyrosine moiety in the original series has been replaced with nonpeptidic functional groups without a substantial loss of binding affinity. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3009 / 3014
页数：6
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