Mammalian cell cycle cyclins

被引：128
作者：
Martinez-Alonso, Diego [1 ,2 ]
Malumbres, Marcos [1 ,2 ]
机构：
[1] Spanish Natl Canc Res Ctr CNIO Madrid, Cell Div, Madrid, Spain
[2] Spanish Natl Canc Res Ctr CNIO Madrid, Canc Grp, Madrid, Spain
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2020年 / 107卷
关键词：
Cancer; Cell cycle; Cell proliferation; Cyclin; Cyclin-dependent kinase; PHOSPHORYLATION-DEPENDENT UBIQUITINATION; ANAPHASE-PROMOTING COMPLEX/CYCLOSOME; HUMAN CDK8 SUBCOMPLEX; MESSENGER-RNA; S-PHASE; PROTEIN-KINASE; MITOCHONDRIAL FISSION; BINDING PROTEIN; P34CDC2; KINASE; A-TYPE;
D O I：
10.1016/j.semcdb.2020.03.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Proper progression throughout the cell division cycle depends on the expression level of a family of proteins known as cyclins, and the subsequent activation of cyclin-dependent kinases (Cdks). Among the numerous members of the mammalian cyclin family, only a few of them, cyclins A, B, C, D and E, are known to display critical roles in the cell cycle. These functions will be reviewed here with a special focus on their relevance in different cell types in vivo and their implications in human disease.
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页码：28 / 35
页数：8
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