Herpes simplex virus encephalitis is a trigger of brain autoimmunity

被引：378

作者：

Armangue, Thais ^{[1
,2
]}

Leypoldt, Frank ^{[1
,3
]}

Malaga, Ignacio ^{[4
]}

Raspall-Chaure, Miquel ^{[2
]}

Marti, Itxaso ^{[5
]}

Nichter, Charles ^{[6
]}

Pugh, John ^{[6
]}

Vicente-Rasoamalala, Monica ^{[7
]}

Lafuente-Hidalgo, Miguel ^{[5
]}

Macaya, Alfons ^{[2
]}

Ke, Michael ^{[8
]}

Titulaer, Maarten J. ^{[9
]}

Hoeftberger, Romana ^{[1
,10
]}

Sheriff, Heather ^{[11
]}

Glaser, Carol ^{[11
]}

Dalmau, Josep ^{[1
,12
,13
]}

机构：

[1] Univ Barcelona, August Pi & Sunyer Biomed Res Inst IDIBAPS, Neurol Serv, Hosp Clin, E-08036 Barcelona, Spain

[2] Autonomous Univ Barcelona, Dept Pediat Neurol, Maternoinfantil Vall dHebron Hosp, Barcelona, Spain

[3] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Hamburg, Germany

[4] Asturias Cent Univ Hosp, Pediat Neurol Unit, Dept Pediat, Oviedo, Spain

[5] Donostia Univ Hosp, Pediat Neurol Sect, San Sebastian, Spain

[6] Albany Med Ctr, Pediat Neurol Serv, Albany, NY USA

[7] Autonomous Univ Barcelona, Pediat Clin Neurophysiol Serv, Maternoinfantil Vall dHebron Hosp, Barcelona, Spain

[8] Stanford Univ, Dept Neurol, Stanford, CA 94305 USA

[9] Erasmus MC, Dept Neurol, Rotterdam, Netherlands

[10] Med Univ Vienna, Inst Neurol, Vienna, Austria

[11] Calif Dept Publ Hlth, Ctr Infect Dis, Richmond, CA USA

[12] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[13] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

来源：

ANNALS OF NEUROLOGY | 2014年 / 75卷 / 02期

关键词：

NMDA-RECEPTOR ENCEPHALITIS; D-ASPARTATE RECEPTOR; COMBINATION THERAPY; ANTIBODIES; RELAPSE; ACYCLOVIR;

D O I：

10.1002/ana.24083

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In 5 prospectively diagnosed patients with relapsing post-herpes simplex encephalitis (HSE), N-methyl-D-aspartate receptor (NMDAR) antibodies were identified. Antibody synthesis started 1 to 4 weeks after HSE, preceding the neurological relapse. Three of 5 patients improved postimmunotherapy, 1 spontaneously, and 1 has started to improve. Two additional patients with NMDAR antibodies, 9 with unknown neuronal surface antibodies, and 1 with NMDAR and unknown antibodies, were identified during retrospective assessment of 34 HSE patients; the frequency of autoantibodies increased over time (serum, p = 0.004; cerebrospinal fluid, p = 0.04). The 3 retrospectively identified NMDAR antibody-positive patients also had evidence of relapsing post-HSE. Overall, these findings indicate that HSE triggers NMDAR antibodies and potentially other brain autoimmunity. Ann Neurol 2014;75:317-323

引用

页码：317 / 323

页数：7

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