Optogenetic and Pharmacologic Dissection of Feedforward Inhibition in Drosophila Motion Vision

被引:76
作者
Mauss, Alex S. [1 ]
Meier, Matthias [1 ]
Serbe, Etienne [1 ]
Borst, Alexander [1 ]
机构
[1] Max Planck Inst Neurobiol, D-82152 Martinsried, Germany
关键词
Drosophila; feedforward inhibition; motion vision; optogenetics; pharmacology; synaptic connectivity; NICOTINIC ACETYLCHOLINE-RECEPTORS; VISUAL-MOTION; SENSITIVE INTERNEURONS; DETECTION PATHWAY; TANGENTIAL CELLS; CENTRAL NEURONS; LOBULA PLATE; GAIN-CONTROL; FLY; SYSTEM;
D O I
10.1523/JNEUROSCI.3938-13.2014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Visual systems extract directional motion information from spatiotemporal luminance changes on the retina. An algorithmic model, the Reichardt detector, accounts for this by multiplying adjacent inputs after asymmetric temporal filtering. The outputs of two mirror-symmetrical units tuned to opposite directions are thought to be subtracted on the dendrites of wide-field motion-sensitive lobula plate tangential cells by antagonistic transmitter systems. In Drosophila, small-field T4/T5 cells carry visual motion information to the tangential cells that are depolarized during preferred and hyperpolarized during null direction motion. While preferred direction input is likely provided by excitation from T4/T5 terminals, the origin of null direction inhibition is unclear. Probing the connectivity between T4/T5 and tangential cells in Drosophila using a combination of optogenetics, electrophysiology, and pharmacology, we found a direct excitatory as well as an indirect inhibitory component. This suggests that the null direction response is caused by feedforward inhibition via yet unidentified neurons.
引用
收藏
页码:2254 / 2263
页数:10
相关论文
共 64 条
  • [1] [Anonymous], 1984, Photoreception and Vision in Invertebrates, DOI DOI 10.1007/978-1-4613-2743-1_15
  • [2] Object tracking in motion-blind flies
    Bahl, Armin
    Ammer, Georg
    Schilling, Tabea
    Borst, Alexander
    [J]. NATURE NEUROSCIENCE, 2013, 16 (06) : 730 - +
  • [3] ACETYLCHOLINE-RECEPTORS OF THORACIC DORSAL MIDLINE NEURONS IN THE COCKROACH, PERIPLANETA-AMERICANA
    BAI, DL
    ERDBRUGGER, H
    BREER, H
    SATTELLE, DB
    [J]. ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 1992, 21 (04) : 289 - 301
  • [4] Acetylcholine, GABA and glutamate induce ionic currents in cultured antennal lobe neurons of the honeybee, Apis mellifera
    Barbara, GS
    Zube, C
    Rybak, J
    Gauthier, M
    Grünewald, B
    [J]. JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 2005, 191 (09): : 823 - 836
  • [5] MECHANISMS OF DENDRITIC INTEGRATION UNDERLYING GAIN-CONTROL IN FLY MOTION-SENSITIVE INTERNEURONS
    BORST, A
    EGELHAAF, M
    HAAG, J
    [J]. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 1995, 2 (01) : 5 - 18
  • [6] Seeing Things in Motion: Models, Circuits, and Mechanisms
    Borst, Alexander
    Euler, Thomas
    [J]. NEURON, 2011, 71 (06) : 974 - 994
  • [7] Fly Motion Vision
    Borst, Alexander
    Haag, Juergen
    Reiff, Dierk F.
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, VOL 33, 2010, 33 : 49 - +
  • [8] Drosophila's View on Insect Vision
    Borst, Alexander
    [J]. CURRENT BIOLOGY, 2009, 19 (01) : R36 - R47
  • [9] Cholinergic and GABAergic receptors on fly tangential cells and their role in visual motion detection
    Brotz, TM
    Borst, A
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1996, 76 (03) : 1786 - 1799
  • [10] Defining the Computational Structure of the Motion Detector in Drosophila
    Clark, Damon A.
    Bursztyn, Limor
    Horowitz, Mark A.
    Schnitzer, Mark J.
    Clandinin, Thomas R.
    [J]. NEURON, 2011, 70 (06) : 1165 - 1177