Antibacterial and antifungal metal based triazole Schiff bases

被引：30

作者：

Chohan, Zahid H. ^{[1
]}

Hanif, Muhammad ^{[1
]}

机构：

[1] Bahauddin Zakariya Univ, Dept Chem, Multan 60800, Pakistan

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2013年 / 28卷 / 05期

关键词：

Antibacterial; antifungal; triazole Schiff bases; metal(II) complexes; IN-VITRO ANTIBACTERIAL; ZINC(II) COMPLEXES; BIOLOGICAL-PROPERTIES; ZN(II) COMPLEXES; COPPER(II); NICKEL(II); COBALT(II); CU(II); CO(II); NI(II);

D O I：

10.3109/14756366.2012.696246

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new series of four biologically active triazole derived Schiff base ligands (L-1-L-4) and their cobalt(II), nickel(II), copper(II) and zinc(II) complexes (1-16) have been synthesized and characterized. The ligands were prepared by the condensation reaction of 3-amino-5-methylthio-1H-1,2,4-triazole with chloro-, bromo- and nitro-substituted 2-hydroxybenzaldehyde in an equimolar ratio. The antibacterial and antifungal bioactivity data showed the metal(II) complexes to be more potent antibacterial and antifungal than the parent Schiff bases against one or more bacterial and fungal species.

引用

页码：944 / 953

页数：10

共 26 条

[1]

Al-Masoudi I., 2006, CHEM HETEROCYC COMPO, V42, P1377, DOI [https://doi.org/10.1007/s10593-006-0255-3, DOI 10.1007/S10593-006-0255-3]

[2] Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases [J].

Bagihalli, Gangadhar B. ;

Avaji, Prakash Gouda ;

Patil, Sangamesh A. ;

Badami, Prema S. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (12) :2639-2649

[3] Microwave assisted synthesis, spectroscopic and antibacterial studies of titanocene chelates of Schiff bases derived from 3-substituted-4-amino-5-hydrazino-1,2,4-triazoles [J].

Banerjee, Priyanka ;

Pandey, Om P. ;

Sengupta, Soumitra K. .

TRANSITION METAL CHEMISTRY, 2008, 33 (08) :1047-1052

[4]

Capranico Giovanni, 2004, Current Medicinal Chemistry - Anti-Cancer Agents, V4, P335, DOI 10.2174/1568011043352885

[5]

Chohan ZH, 2008, J ENZYM INHIB MED CH, V23, P240, DOI [10.1080/14756360701474913, 10.1080/14756360701474913 ]

[6] Metalloantibiotics:: Synthesis, characterization and in-vitro antibacterial studies on cobalt(II), copper(II), nickel(II) and zinc(II) complexes with cloxacillin [J].

Chohan, Zahid H. ;

Supuran, Claudiu T. .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2006, 21 (04) :441-448

[7] Antibacterial dimeric copper(II) complexes with chromone-derived compounds [J].

Chohan, Zahid H. ;

Iqbal, Mohammad S. ;

Aftab, Syed K. ;

Rauf, A. .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2012, 27 (02) :223-231

[8] Synthesis, characterization and biological studies of oxovanadium(IV) complexes with triazole-derived Schiff bases [J].

Chohan, Zahid H. ;

Sumrra, Sajjad H. .

APPLIED ORGANOMETALLIC CHEMISTRY, 2010, 24 (02) :122-130

[9] Metal-based antibacterial and antifungal sulfonamides: synthesis, characterization, and biological properties [J].

Chohan, Zahid H. .

TRANSITION METAL CHEMISTRY, 2009, 34 (02) :153-161

[10] Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) complexes of thiadiazole derived furanyl, thiophenyl and pyrrolyl Schiff bases [J].

Chohan, ZH ;

Pervez, H ;

Rauf, A ;

Scozzafava, A ;

Supuran, CT .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2002, 17 (02) :117-122

← 1 2 3 →