Effect of L-arginine in central spinal pain syndrome

被引：0

作者：

Danilova, EI ^{[1
]}

Grafova, VN ^{[1
]}

Kukushkin, ML ^{[1
]}

Zinkevich, VA ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Gen Pathol & Pathol Physiol, Moscow 125315, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 127卷 / 02期

关键词：

L-arginine; nitric oxide; central spinal pain syndrome; kyotorphin;

D O I：

10.1007/BF02433097

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

When applied in combination with penicillin (2000 U) to the dorsal surface of the spinal cord, L-arginine in a low concentration of 100 nmol had a pronociceptive effect, while being applied in concentrations of 65-130 mu mol with penicillin or injected intramuscularly before penicillin (15,000 U) L-arginine exhibited an analgesic effect. The opposite effects of L-arginine as the demonstrated. precursor of NO and of opioid dipeptide kyotorphin are demonstrated.

引用

页码：144 / 147

页数：4

共 15 条

[1] NITRIC-OXIDE, A NOVEL NEURONAL MESSENGER [J].

BREDT, DS ;

SNYDER, SH .

NEURON, 1992, 8 (01) :3-11

[2] ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME [J].

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :682-685

[3] PERIPHERAL ANALGESIA AND ACTIVATION OF THE NITRIC OXIDE-CYCLIC GMP PATHWAY [J].

DUARTE, IDG ;

LORENZETTI, BB ;

FERREIRA, SH .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 186 (2-3) :289-293

[4] ELECTROPHYSIOLOGICAL EVIDENCE FOR A ROLE OF NITRIC-OXIDE IN PROLONGED CHEMICAL NOCICEPTION IN THE RAT [J].

HALEY, JE ;

DICKENSON, AH ;

SCHACHTER, M .

NEUROPHARMACOLOGY, 1992, 31 (03) :251-258

[5] MEMBRANE DEPOLARIZATION AND PROLONGATION OF CALCIUM-DEPENDENT ACTION-POTENTIALS OF MOUSE NEURONS IN CELL-CULTURE BY 2 CONVULSANTS - BICUCULLINE AND PENICILLIN [J].

HEYER, EJ ;

NOWAK, LM ;

MACDONALD, RL .

BRAIN RESEARCH, 1982, 232 (01) :41-56

[6] L-LEUCYL-L-ARGININE, NALTRINDOLE AND D-ARGININE BLOCK ANTINOCICEPTION ELICITED BY L-ARGININE IN MICE WITH CARRAGEENAN-INDUCED HYPERALGESIA [J].

KAWABATA, A ;

NISHIMURA, Y ;

TAKAGI, H .

BRITISH JOURNAL OF PHARMACOLOGY, 1992, 107 (04) :1096-1101

[7] EFFECT OF TOPICAL ADMINISTRATION OF L-ARGININE ON FORMALIN-INDUCED NOCICEPTION IN THE MOUSE - A DUAL ROLE OF PERIPHERALLY FORMED NO IN PAIN MODULATION [J].

KAWABATA, A ;

MANABE, S ;

MANABE, Y ;

TAKAGI, H .

BRITISH JOURNAL OF PHARMACOLOGY, 1994, 112 (02) :547-550

[8]

Kryzhanovskii G. N., 1997, GEN PATHOPHYSIOLOGY

[9] SPINAL NITRIC-OXIDE SYNTHESIS INHIBITION BLOCKS NMDA-INDUCED THERMAL HYPERALGESIA AND PRODUCES ANTINOCICEPTION IN THE FORMALIN TEST IN RATS [J].

MALMBERG, AB ;

YAKSH, TL .

PAIN, 1993, 54 (03) :291-300

[10] EXCITATORY AMINO-ACID RECEPTORS, 2ND MESSENGERS AND REGULATION OF INTRACELLULAR CA-2+ IN MAMMALIAN NEURONS [J].

MAYER, ML ;

MILLER, RJ .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (06) :254-260

← 1 2 →