Thromboinflammation in Therapeutic Medicine

被引：30

作者：

Ekdahl, Kristina N. ^{[1
]}

Teramura, Yuji ^{[2
]}

Asif, Sana ^{[3
]}

Jonsson, Nina ^{[3
,4
]}

Magnusson, Peetra U. ^{[3
]}

Nilsson, Bo ^{[1
]}

机构：

[1] Uppsala Univ, Immunol Genet & Pathol, Uppsala, Sweden

[2] Univ Tokyo, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan

[3] Uppsala Univ, Dept Immunol Genet & Pathol IGP, Rudbeck Lab C5 3, S-75185 Uppsala, Sweden

[4] Linnaeus Univ, Linnaeus Ctr Biomat Chem, S-39182 Kalmar, Sweden

来源：

IMMUNE RESPONSES TO BIOSURFACES: MECHANISMS AND THERAPEUTIC INTERVENTIONS | 2015年 / 865卷

基金：

瑞典研究理事会; 日本学术振兴会;

关键词：

Coagulation; Complement; Extracorporeal treatment; Platelets; Therapeutic medicine; Thromboinflammation; MEDIATED INFLAMMATORY REACTION; GLYCOPROTEIN IB-ALPHA; COMPLEMENT ACTIVATION; CONTACT ACTIVATION; WHOLE-BLOOD; ENDOTHELIAL GLYCOCALYX; INHIBITS COMPLEMENT; BIOMATERIAL SURFACE; HUMAN PLATELETS; INTEGRIN MAC-1;

D O I：

10.1007/978-3-319-18603-0_1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thromboinflammation is primarily triggered by the humoral innate immune system, which mainly consists of the cascade systems of the blood, i.e., the complement, contact/coagulation and fibrinolytic systems. Activation of these systems subsequently induces activation of endothelial cells, leukocytes and platelets, finally resulting in thrombotic and inflammatory reactions. Such reactions are triggered by a number of medical procedures, e.g., treatment with biomaterials or drug delivery devices as well as in transplantation with cells, cell clusters or whole vascularized organs. Here, we (1) describe basic mechanisms for thromboinflammation; (2) review thromboinflammatory reactions in therapeutic medicine; and (3) discuss emerging strategies to dampen thromboinflammation.

引用

页码：3 / 17

页数：15

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