TRPA1 and other TRP channels in migraine

被引:65
作者
Benemei, Silvia [1 ]
De Cesaris, Francesco
Fusi, Camilla
Rossi, Eleonora
Lupi, Chiara
Geppetti, Pierangelo
机构
[1] Univ Florence, Careggi Univ Hosp, Dept Hlth Sci, Headache Ctr, I-50139 Florence, Italy
关键词
Migraine; Transient receptor potential ankyrin 1 (TRPA1); Transient receptor potential vanilloid 1 (TRPV1); Calcitonin gene-related peptide (CGRP); Neurogenic inflammation; ThermoTRP; Headache; Pain; RECEPTOR POTENTIAL A1; NITRIC-OXIDE; SENSORY NEURONS; ION-CHANNEL; CHRONIC-PANCREATITIS; CATION CHANNEL; ALPHA; BETA-UNSATURATED ALDEHYDES; TRIGEMINOVASCULAR SYSTEM; NEUROGENIC INFLAMMATION; COVALENT MODIFICATION;
D O I
10.1186/1129-2377-14-71
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Ever since their identification, interest in the role of transient receptor potential (TRP) channels in health and disease has steadily increased. Robust evidence has underlined the role of TRP channels expressed in a subset of primary sensory neurons of the trigeminal ganglion to promote, by neuronal excitation, nociceptive responses, allodynia and hyperalgesia. In particular, the TRP vanilloid 1 (TRPV1) and the TRP ankyrin 1 (TRPA1) are expressed in nociceptive neurons, which also express the sensory neuropeptides, tachykinins, and calcitonin gene-related peptide (CGRP), which mediate neurogenic inflammatory responses. Of interest, CGRP released from the trigeminovascular network of neurons is currently recognized as a main contributing mechanism of migraine attack. The ability of TRPA1 to sense and to be activated by an unprecedented series of exogenous and endogenous reactive molecules has now been extensively documented. Several of the TRPA1 activators are also known as triggers of migraine attack. Thus, TRP channels, and particularly TRPA1, may be proposed as novel pathways in migraine pathophysiology and as possible new targets for its treatment.
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页数:8
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