Coronary microvascular dysfunction in hypertrophic cardiomyopathy: Pathophysiology, assessment, and clinical impact

被引：37

作者：

Aguiar Rosa, Silvia ^{[1
,2
]}

Rocha Lopes, Luis ^{[3
,4
,5
]}

Fiarresga, Antonio ^{[1
]}

Ferreira, Rui Cruz ^{[1
]}

Mota Carmo, Miguel ^{[2
]}

机构：

[1] Santa Marta Hosp, Dept Cardiol, Lisbon, Portugal

[2] Nova Med Sch, Lisbon, Portugal

[3] St Bartholomews Hosp, Inherited Cardiac Dis Unit, Barts Heart Ctr, London, England

[4] UCL, Inst Cardiovasc Sci, Ctr Heart Muscle Dis, London, England

[5] Univ Lisbon, Ctr Cardiovasc, Lisbon, Portugal

来源：

MICROCIRCULATION | 2021年 / 28卷 / 01期

关键词：

hypertrophic cardiomyopathy; microcirculatory dysfunction; CONVERTING ENZYME-INHIBITION; MYOCARDIAL-PERFUSION ABNORMALITIES; CARDIOVASCULAR MAGNETIC-RESONANCE; LEFT-VENTRICULAR HYPERTROPHY; ALCOHOL SEPTAL ABLATION; BLOOD-FLOW; VASODILATOR RESERVE; EUROPEAN ASSOCIATION; SUBENDOCARDIAL ISCHEMIA; SYSTOLIC DYSFUNCTION;

D O I：

10.1111/micc.12656

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myocardial ischemia constitutes one of the most important pathophysiological features in hypertrophic cardiomyopathy. Chronic and recurrent myocardial ischemia leads to fibrosis, which may culminate in myocardial dysfunction. Since the direct visualization of coronary microcirculation in vivo is not possible, its function must be studied indirectly. Invasive and noninvasive techniques allow microcirculatory dysfunction to be evaluated, including echocardiography, magnetic resonance, positron emission tomography, and cardiac catheterization. Blunted myocardial blood flow and coronary flow reserve have been suggested to associate with unfavorable prognosis. Microcirculatory dysfunction may be one additional important parameter to take into account for risk stratification beyond the conventional risk factors.

引用

页数：17

共 120 条

[1] Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy [J].

Abozguia, Khalid ;

Elliott, Perry ;

McKenna, William ;

Phan, Thanh Trung ;

Nallur-Shivu, Ganesh ;

Ahmed, Ibrar ;

Maher, Abdul R. ;

Kaur, Kulvinder ;

Taylor, Jenny ;

Henning, Anke ;

Ashrafian, Houman ;

Watkins, Hugh ;

Frenneaux, Michael .

CIRCULATION, 2010, 122 (16) :1562-U56

[2] SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob-/- mice [J].

Adingupu, Damilola D. ;

Gopel, Sven O. ;

Gronros, Julia ;

Behrendt, Margareta ;

Sotak, Matus ;

Miliotis, Tasso ;

Dahlqvist, Ulrika ;

Gan, Li-Ming ;

Jonsson-Rylander, Ann-Cathrine .

CARDIOVASCULAR DIABETOLOGY, 2019, 18 (1)

[3]

Akasaka T, 1994, J Am Soc Echocardiogr, V7, P9

[4] Augmentation of myocardial blood flow in hypertensive heart disease by angiotensin antagonists - A comparison of lismopril and losartan [J].

Akinboboye, OO ;

Chou, RL ;

Bergmann, SR .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (04) :703-709

[5] Hypertrophic cardiomyopathy and sudden death in the young: Pathologic evidence of myocardial ischemia [J].

Basso, C ;

Thiene, G ;

Corrado, D ;

Buja, G ;

Melacini, P ;

Nava, A .

HUMAN PATHOLOGY, 2000, 31 (08) :988-998

[6] Myocardial bridging, a frequent component of the hypertrophic cardiomyopathy phenotype, lacks systematic association with sudden cardiac death [J].

Basso, Cristina ;

Thiene, Gaetano ;

Mackey-Bojack, Shannon ;

Frigo, Anna Chiara ;

Corrado, Domenico ;

Maron, Barry J. .

EUROPEAN HEART JOURNAL, 2009, 30 (13) :1627-1634

[7] Contribution of endothelium-derived hyperpolarizing factors to the regulation of vascular tone in humans [J].

Bellien, Jeremy ;

Thuillez, Christian ;

Joannides, Robinson .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2008, 22 (04) :363-377

[8] Contribution of Adenosine A2A and A2B Receptors to Ischemic Coronary Dilation: Role of KV and KATP Channels [J].

Berwick, Zachary C. ;

Payne, Gregory A. ;

Lynch, Brandon ;

Dick, Gregory M. ;

Sturek, Michael ;

Tune, Johnathan D. .

MICROCIRCULATION, 2010, 17 (08) :600-607

[9] MR Imaging in Hypertrophic Cardiomyopathy: From Magnet to Bedside [J].

Bogaert, Jan ;

Olivotto, Iacono .

RADIOLOGY, 2014, 273 (02) :328-347

[10] Incidence and predictors of microvascular dysfunction assessed by the index of microcirculatory resistance following primary PCI for ST-elevation myocardial infarction [J].

Bonello, Laurent ;

Mokhtar, Omar Ait ;

Lemesle, Gilles ;

Mancini, Julien ;

Burignat-Bonello, Caroline ;

Jacquier, Alexis ;

Armero, Sebastien ;

Zerrouk, Zinedine ;

Benhamou, Lionel ;

Yvorra, Serge ;

Paganelli, Franck .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2011, 146 (03) :465-467

← 1 2 3 4 5 6 7 8 9 10 →