Investigation of the potential of using TiO2 nanoparticles as a contrast agent in computed tomography and magnetic resonance imaging

被引：11

作者：

Akasaka, Hiroaki ^{[1
]}

Mukumoto, Naritoshi ^{[1
]}

Nakayama, Masao ^{[2
]}

Wang, Tianyuan ^{[3
]}

Yada, Ryuichi ^{[3
]}

Shimizu, Yasuyuki ^{[3
]}

Inubushi, Sachiko ^{[3
]}

Kyotani, Katsusuke ^{[4
]}

Okumura, Keisuke ^{[4
]}

Miyamoto, Masanori ^{[4
]}

Nakaoka, Ai ^{[3
]}

Morita, Kenta ^{[5
]}

Nishimura, Yuya ^{[5
]}

Ogino, Chiaki ^{[5
]}

Sasaki, Ryohei ^{[1
]}

机构：

[1] Kobe Univ Hosp, Div Radiat Oncol, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] RMIT Univ, Div Med Radiat, Sch Hlth & Biomed Sci, Plenty Rd, Bundoora, Vic 3083, Australia

[3] Kobe Univ, Div Radiat Oncol, Grad Sch Med, Chuo Ku, Kobe, Hyogo 6500017, Japan

[4] Kobe Univ Hosp, Ctr Radiol & Radiat Oncol, Chuo Ku, Kobe, Hyogo 6500017, Japan

[5] Kobe Univ, Grad Sch Engn, Dept Chem Sci & Engn, Nada Ku, 1-1 Rokkoudaicho, Kobe, Hyogo 6578501, Japan

来源：

APPLIED NANOSCIENCE | 2020年 / 10卷 / 08期

基金：

日本学术振兴会;

关键词：

Nanoparticle; Titanium oxide; Theranostic; MRI; CT; Radiotherapy; ADMINISTERED TITANIUM-DIOXIDE; PHOTODYNAMIC THERAPY; GOLD NANOPARTICLES; GENERATION;

D O I：

10.1007/s13204-019-01098-y

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Nanoparticles (NPs) are useful for radiotherapy. Currently, efforts are underway globally for the development of novel titanium dioxide NPs (TiO2-NPs) that exhibit both contrast effects and anti-tumor effects. In this study, the image contrast properties of TiO2-NPs were evaluated using a clinical magnetic resonance imaging (MRI) system and a clinical computed tomography (CT) scanner, as the use of TiO2-NPs as an anti-cancer agent has been reported in several reports. An obvious difference in visualization was observed between the control and TiO2-NP samples onT(2)-weighted images. These results suggest that TiO(2)can potentially be used as a novel theranostic drug with radiosensitizing ability and radiological diagnostic ability, through modification of chemical groups on its surface, and as a component of drug delivery systems.

引用

页码：3143 / 3148

页数：6

共 29 条

[1] MGDG extracted from spinach enhances the cytotoxicity of radiation in pancreatic cancer cells [J].