A mild, efficient and one-pot synthesis of 2-substituted benzimidazoles by ZrOCl2.8H2O catalyzed ring closure reaction

被引：0

作者：

Reddy, Ch Sanjeeva ^{[1
]}

Nagaraj, A. ^{[1
]}

机构：

[1] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2008年 / 47卷 / 07期

关键词：

ZrOCl2.8H(2)O; benzimidazole; orthoester; microwave irradiation;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild, efficient and one-pot synthesis of an array of 2-substituted benzimidazoles from an appropriate o-phenylenediamine and orthoesters such as orthoformate, orthoacetate and orthovalerate using ZrOCl2.8H(2)O. at room temperature and under microwave irradiation is described. Ecofriendly, solvent-Free methodology has been employed under microwave condition. Compared with the conventional method, microwave irradiation method has the advantages of excellent yields (81-93%) and shorter reaction time (5-10 min).

引用

页码：1154 / 1159

页数：6

共 69 条

[1]

Akbay A, 2003, ARZNEIMITTELFORSCH, V53, P266

[2] Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: Inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells [J].

Beaulieu, PL ;

Bousquet, Y ;

Gauthier, J ;

Gillard, J ;

Marquis, M ;

McKercher, G ;

Pellerin, C ;

Valois, S ;

Kukolj, G .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (27) :6884-6892

[3]

BOURUAH CR, 1994, J MED CHEM, V37, P1625

[4]

Carlos R.D., 2007, TETRAHEDRON LETT, V48, P5777

[5] Synthesis of benzimidazole based analogues of sphingosine-1-phosphate:: discovery of potent, subtype-selective S1P4 receptor agonists [J].

Clemens, JJ ;

Davis, MD ;

Lynch, KR ;

Macdonald, TL .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (19) :4903-4906

[6] Synthesis of benzimidazoles in high-temperature water [J].

Dudd, LM ;

Venardou, E ;

Garcia-Verdugo, E ;

Licence, P ;

Blake, AJ ;

Wilson, C ;

Poliakoff, M .

GREEN CHEMISTRY, 2003, 5 (02) :187-192

[7] A mild and efficient one-pot synthesis of 2-dihydroimidazoles from aldehydes [J].

Fujioka, H ;

Murai, K ;

Ohba, Y ;

Hiramatsu, A ;

Kita, Y .

TETRAHEDRON LETTERS, 2005, 46 (13) :2197-2199

[8] HETEROCYCLES FROM N-ETHOXYCARBONYLTHIOAMIDES AND DINUCLEOPHILIC REAGENTS .2. 5-MEMBERED RINGS CONTAINING 2 HETEROATOMS AT 1,3 POSITIONS [J].

GEORGE, B ;

PAPADOPOULOS, EP .

JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (03) :441-443

[9]

GOGI P, 2006, TETRAHEDRON LETT, V47, P79, DOI DOI 10.1016/J.TETLET.2005.10.134

[10]

HABIB F, 2006, J MOL CATAL, V252, P150

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